Overview

  • Product name

  • Description

    Rabbit polyclonal to DOCK6
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Recombinant fragment corresponding to Human DOCK6 aa 803-904.
    Sequence:

    GAFEAMAHVVSLVHRSLEAAQDARGHCPQLAAYVHYAFRLPGTEPSLPDG APPVTVQAATLARGSGRPASLYLARSKSISSSNPDLAVAPGSVDDEVSRI LA


    Database link: Q96HP0

  • Positive control

    • Human stomach, pancreas and pancreatic cancer tissue.
  • General notes

     This product was previously labelled as Dedicator of cytokinesis protein 6

     

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer

    pH: 7.2
    Preservative: 0.02% Sodium azide
    Constituents: 59% PBS, 40% Glycerol
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab188445 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/500 - 1/1000. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Function

    Acts as guanine nucleotide exchange factor (GEF) for CDC42 and RAC1 small GTPases. Through its activation of CDC42 and RAC1, may regulate neurite outgrowth.
  • Tissue specificity

    Widely expressed. Expressed at low level in spleen, cerebellum, hippocampus and in substantia nigra.
  • Involvement in disease

    Adams-Oliver syndrome 2
  • Sequence similarities

    Belongs to the DOCK family.
    Contains 1 DHR-1 domain.
    Contains 1 DHR-2 domain.
  • Domain

    The DHR-2 domain may mediate some GEF activity.
  • Cellular localization

    Cytoplasm. Cytoplasm > perinuclear region. Mainly located near the cell surface.
  • Information by UniProt
  • Database links

  • Alternative names

    • Dedicator of cytokinesis protein 6 antibody
    • Dock6 antibody
    • DOCK6_HUMAN antibody

Images

  • Immunohistochemical analysis of paraffin-embedded Human stomach tissue labeling DOCK6 with ab188445 at 1/500 dilution.

  • Immunohistochemical analysis of paraffin-embedded Human pancreas tissue labeling DOCK6 with ab188445 at 1/500 dilution.

  • Immunohistochemical analysis of paraffin-embedded Human pancreatic cancer tissue labeling DOCK6 with ab188445 at 1/500 dilution.

References

ab188445 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab188445.
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