Key features and details
- Rabbit polyclonal to DOCK6
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
Product nameAnti-DOCK6 antibody
See all DOCK6 primary antibodies
DescriptionRabbit polyclonal to DOCK6
Tested applicationsSuitable for: IHC-Pmore details
Species reactivityReacts with: Human
Predicted to work with: Mouse, Rat
- Human stomach, pancreas and pancreatic cancer tissue.
This product was previously labelled as Dedicator of cytokinesis protein 6
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Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.
We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.
In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
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Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferpH: 7.20
Preservative: 0.02% Sodium azide
Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine)
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab188445 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-P||1/500 - 1/1000. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.|
FunctionActs as guanine nucleotide exchange factor (GEF) for CDC42 and RAC1 small GTPases. Through its activation of CDC42 and RAC1, may regulate neurite outgrowth.
Tissue specificityWidely expressed. Expressed at low level in spleen, cerebellum, hippocampus and in substantia nigra.
Involvement in diseaseAdams-Oliver syndrome 2
Sequence similaritiesBelongs to the DOCK family.
Contains 1 DHR-1 domain.
Contains 1 DHR-2 domain.
DomainThe DHR-2 domain may mediate some GEF activity.
Cellular localizationCytoplasm. Cytoplasm > perinuclear region. Mainly located near the cell surface.
- Information by UniProt
- Dedicator of cytokinesis protein 6 antibody
- Dock6 antibody
- DOCK6_HUMAN antibody
Immunohistochemical analysis of paraffin-embedded Human stomach tissue labeling DOCK6 with ab188445 at 1/500 dilution.
Immunohistochemical analysis of paraffin-embedded Human pancreas tissue labeling DOCK6 with ab188445 at 1/500 dilution.
Immunohistochemical analysis of paraffin-embedded Human pancreatic cancer tissue labeling DOCK6 with ab188445 at 1/500 dilution.
ab188445 has not yet been referenced specifically in any publications.