Anti-DOCK6 antibody (ab188558)
Key features and details
- Rabbit polyclonal to DOCK6
- Suitable for: ICC/IF, IHC-P
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-DOCK6 antibody -
Description
Rabbit polyclonal to DOCK6 -
Host species
Rabbit -
Tested applications
Suitable for: ICC/IF, IHC-Pmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Mouse, Rat -
Immunogen
Recombinant fragment corresponding to Human DOCK6 aa 1150-1300.
Database link: Q96HP0 -
Positive control
- IHC-P: Human liver tissue. ICC/IF: U-2 OS cells.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
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Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.20
Preservative: 0.02% Sodium azide
Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine) -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab188558 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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ICC/IF |
Use a concentration of 0.25 - 2 µg/ml.
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IHC-P |
1/500 - 1/1000. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
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Notes |
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ICC/IF
Use a concentration of 0.25 - 2 µg/ml. |
IHC-P
1/500 - 1/1000. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
Target
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Function
Acts as guanine nucleotide exchange factor (GEF) for CDC42 and RAC1 small GTPases. Through its activation of CDC42 and RAC1, may regulate neurite outgrowth. -
Tissue specificity
Widely expressed. Expressed at low level in spleen, cerebellum, hippocampus and in substantia nigra. -
Involvement in disease
Adams-Oliver syndrome 2 -
Sequence similarities
Belongs to the DOCK family.
Contains 1 DHR-1 domain.
Contains 1 DHR-2 domain. -
Domain
The DHR-2 domain may mediate some GEF activity. -
Cellular localization
Cytoplasm. Cytoplasm > perinuclear region. Mainly located near the cell surface. - Information by UniProt
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Database links
- Entrez Gene: 57572 Human
- SwissProt: Q96HP0 Human
- Unigene: 591002 Human
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Alternative names
- Dedicator of cytokinesis protein 6 antibody
- Dock6 antibody
- DOCK6_HUMAN antibody
Images
Datasheets and documents
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SDS download
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Datasheet download
References (0)
ab188558 has not yet been referenced specifically in any publications.