Recombinant
RabMAb

Recombinant Anti-DOCK8 antibody [EPR12511-56] - BSA and Azide free (ab250048)

Overview

  • Product name

    Anti-DOCK8 antibody [EPR12511-56] - BSA and Azide free
    See all DOCK8 primary antibodies
  • Description

    Rabbit monoclonal [EPR12511-56] to DOCK8 - BSA and Azide free
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
    Unsuitable for: Flow Cyt,ICC/IF,IHC or IP
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Recombinant fragment within Human DOCK8. The exact sequence is proprietary.
    Database link: Q8NF50

  • General notes

    ab250048 is the carrier-free version of ab178427 This format is designed for use in antibody labeling, including fluorochromes, metal isotopes, oligonucleotides, enzymes.

     

    Our carrier-free formats are supplied in a buffer free of BSA, sodium azide and glycerol for higher conjugation efficiency.

    Use our conjugation kits  for antibody conjugates that are ready-to-use in as little as 20 minutes with <1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.

    Ab250048 is compatible with the Maxpar® Antibody Labeling Kit from Fluidigm.

    Maxpar® is a trademark of Fluidigm Canada Inc.

    Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents.

    This product is a recombinant rabbit monoclonal antibody.

Properties

Applications

Our Abpromise guarantee covers the use of ab250048 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use at an assay dependent concentration. Predicted molecular weight: 239 kDa.
  • Application notes
    Is unsuitable for Flow Cyt,ICC/IF,IHC or IP.
  • Target

    • Function

      Potential guanine nucleotide exchange factor (GEF). GEF proteins activate some small GTPases by exchanging bound GDP for free GTP.
    • Involvement in disease

      Defects in DOCK8 are the cause of hyperimmunoglobulin E recurrent infection syndrome autosomal recessive (AR-HIES) [MIM:243700]. It is a rare disorder of immunity characterized by immunodeficiency, recurrent infections, eczema, increased serum IgE, eosinophilia and lack of connective tissue and skeletal involvement.
    • Sequence similarities

      Belongs to the DOCK family.
      Contains 1 DHR-1 (CZH-1) domain.
      Contains 1 DHR-2 (CZH-2) domain.
    • Domain

      The DHR-2 domain may mediate some GEF activity.
    • Information by UniProt
    • Database links

    • Alternative names

      • 1200017A24Rik antibody
      • Dedicator of cytokinesis protein 8 antibody
      • DOCK8 antibody
      • DOCK8_HUMAN antibody
      • Epididymis luminal protein 205 antibody
      • HEL 205 antibody
      • MRD2 antibody
      • ZIR8 antibody
      see all

    References

    ab250048 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

    There are currently no Customer reviews or Questions for ab250048.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
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