Docosa-4Z,7Z,10Z,13Z,16Z,19Z-hexaenoic acid, Anti-inflammatory agent (ab145212)

Overview

  • Product name

    Docosa-4Z,7Z,10Z,13Z,16Z,19Z-hexaenoic acid, Anti-inflammatory agent
  • Description

    Polyunsaturated fatty acid; anti-inflammatory agent
  • Alternative names

    • (4Z,7Z,10Z,13Z,16Z,19Z)-4,7,10,13,16,19-Docosahexaenoic acid
    • 22:6(n-3)
    • all-cis-docosa-4,7,10,13,16,19-hexa-enoic acid
    • cervonic acid
    • DHA
    • Docosahexaenoic acid
    see all
  • Biological description

    Abundant essential n-3 polyunsaturated fatty acid in the CNS, shown to play a major anti-inflammatory role. Prevents LPS-induced dendritic cell maturation, characterized by a lack of proinflammatory cytokine production. Improves the nitroso-redox balance and reduces VEGF-mediated angiogenic signaling in microvascular endothelial cells. Inhibits Aβ1-42 fibrillation and toxicity in vitro. Retinoid X receptor (RXR) ligand.

  • Purity

    > 98%
  • CAS Number

    6217-54-5
  • Chemical structure

    Chemical Structure

Properties

  • Molecular weight

    328.50
  • Molecular formula

    C22H32O2
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in ethanol
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

References

This product has been referenced in:

  • Kong W  et al. Docosahexaenoic acid prevents dendritic cell maturation, inhibits antigen-specific Th1/Th17 differentiation and suppresses experimental autoimmune encephalomyelitis. Brain Behav Immun 25:872-82 (2011). Read more (PubMed: 20854895) »
  • Cho JY  et al. Oral administration of docosahexaenoic acid attenuates colitis induced by dextran sulfate sodium in mice. Mol Nutr Food Res 55:239-46 (2011). Read more (PubMed: 20824662) »
  • Matesanz N  et al. Docosahexaenoic acid improves the nitroso-redox balance and reduces VEGF-mediated angiogenic signaling in microvascular endothelial cells. Invest Ophthalmol Vis Sci 51:6815-25 (2010). Read more (PubMed: 20702831) »
  • Hossain S  et al. Mechanism of docosahexaenoic acid-induced inhibition of in vitro Abeta1-42 fibrillation and Abeta1-42-induced toxicity in SH-S5Y5 cells. J Neurochem 111:568-79 (2009). Read more (PubMed: 19686246) »
  • de Urquiza AM  et al. Docosahexaenoic acid, a ligand for the retinoid X receptor in mouse brain. Science 290:2140-4 (2000). Read more (PubMed: 11118147) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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