Product nameDocosa-4Z,7Z,10Z,13Z,16Z,19Z-hexaenoic acid, Anti-inflammatory agent
DescriptionPolyunsaturated fatty acid; anti-inflammatory agent
- (4Z,7Z,10Z,13Z,16Z,19Z)-4,7,10,13,16,19-Docosahexaenoic acid
- all-cis-docosa-4,7,10,13,16,19-hexa-enoic acid
Abundant essential n-3 polyunsaturated fatty acid in the CNS, shown to play a major anti-inflammatory role. Prevents LPS-induced dendritic cell maturation, characterized by a lack of proinflammatory cytokine production. Improves the nitroso-redox balance and reduces VEGF-mediated angiogenic signaling in microvascular endothelial cells. Inhibits Aβ1-42 fibrillation and toxicity in vitro. Retinoid X receptor (RXR) ligand.
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in ethanol
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
This product has been referenced in:
- Kong W et al. Docosahexaenoic acid prevents dendritic cell maturation, inhibits antigen-specific Th1/Th17 differentiation and suppresses experimental autoimmune encephalomyelitis. Brain Behav Immun 25:872-82 (2011). Read more (PubMed: 20854895) »
- Cho JY et al. Oral administration of docosahexaenoic acid attenuates colitis induced by dextran sulfate sodium in mice. Mol Nutr Food Res 55:239-46 (2011). Read more (PubMed: 20824662) »
- Matesanz N et al. Docosahexaenoic acid improves the nitroso-redox balance and reduces VEGF-mediated angiogenic signaling in microvascular endothelial cells. Invest Ophthalmol Vis Sci 51:6815-25 (2010). Read more (PubMed: 20702831) »
- Hossain S et al. Mechanism of docosahexaenoic acid-induced inhibition of in vitro Abeta1-42 fibrillation and Abeta1-42-induced toxicity in SH-S5Y5 cells. J Neurochem 111:568-79 (2009). Read more (PubMed: 19686246) »
- de Urquiza AM et al. Docosahexaenoic acid, a ligand for the retinoid X receptor in mouse brain. Science 290:2140-4 (2000). Read more (PubMed: 11118147) »