Overview

  • Product name

    Dofetilide, hERG K+ channel blocker
  • Description

    Antiarrhythmic agent. Potent and selective hERG K+ channel blocker
  • Biological description

    Potent and selective hERG K+ channel blocker. Selectively blocks the rapid component of the delayed rectifier outward potassium current. Class III antiarrhythmic agent. Increases the atrial refractory period in vivo. Orally active.
  • Purity

    > 98%
  • CAS Number

    115256-11-6
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    1-(4-Methanesulfonamidophenoxy)-2-[N-(4-methanesulfonamidophenethyl)-N-methylamino]ethane
  • Molecular weight

    441.56
  • Molecular formula

    C19H27N3O5S2
  • PubChem identifier

    71329
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 50 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CN(CCC1=CC=C(C=C1)NS(=O)(=O)C)CCOC2=CC=C(C=C2)NS(=O)(=O)C
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Yu Z  et al. Allosteric modulators of the hERG K(+) channel: radioligand binding assays reveal allosteric characteristics of dofetilide analogs. Toxicol Appl Pharmacol 274:78-86 (2014). Read more (PubMed: 24200993) »
  • Nilsson MF  et al. The effect on rat embryonic heart rate of Na+, K+, and Ca2+ channel blockers, and the human teratogen phenytoin, changes with gestational age. Birth Defects Res B Dev Reprod Toxicol 98:416-27 (2013). Read more (PubMed: 24323366) »
  • Springer C & Sokolnicki KL A fingerprint pair analysis of hERG inhibition data. Chem Cent J 7:167 (2013). Read more (PubMed: 24144230) »

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