Recombinant
RabMAb

Recombinant Anti-DOK5 antibody [EPR9923(B)] (ab168343)

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Overview

  • Product name

    Anti-DOK5 antibody [EPR9923(B)]
    See all DOK5 primary antibodies

  • Description

    Rabbit monoclonal [EPR9923(B)] to DOK5

  • Host species

    Rabbit

  • Tested applications

    Suitable for: WBmore details
    Unsuitable for: Flow Cyt,ICC/IF,IHC-P or IP

  • Species reactivity

    Reacts with: Mouse, Rat, Human

  • Immunogen

    Synthetic peptide corresponding to Human DOK5.
    Database link: Q9P104

  • Positive control

    • IM9, Human fetal brain and Human fetal heart lysates.

  • General notes

     

     

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents.

    This product is a recombinant rabbit monoclonal antibody.

Properties

Applications

Our Abpromise guarantee covers the use of ab168343 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/10000 - 1/50000. Detects a band of approximately 35 kDa (predicted molecular weight: 35 kDa).
  • Application notes
    Is unsuitable for Flow Cyt,ICC/IF,IHC-P or IP.

    • Target

    • Function

      DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK5 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway. Putative link with downstream effectors of RET in neuronal differentiation.

    • Tissue specificity

      Highest expression in skeletal muscle, lower in brain, heart and kidney. Also detected in activated peripheral blood T-lymphocytes.

    • Sequence similarities

      Belongs to the DOK family. Type B subfamily.
      Contains 1 IRS-type PTB domain.
      Contains 1 PH domain.

    • Domain

      PTB domain mediates receptor interaction.

    • Post-translational
      modifications

      Phosphorylated on tyrosine residues in response to insulin, IGF1 and GDNF.
    • Information by UniProt

    • Database links

      • Alternative names

        • chromosome 20 open reading frame 180 antibody
        • Docking protein 5 antibody
        • DOK 5 antibody
        • DOK5 antibody
        • DOK5 protein antibody
        • DOK5_HUMAN antibody
        • Downstream of tyrosine kinase 5 antibody
        • Insulin receptor substrate 6 antibody
        • IRS-6 antibody
        • IRS6 antibody
        see all

      Images

      • Western blot - Anti-DOK5 antibody [EPR9923(B)] (ab168343)
        Western blot - Anti-DOK5 antibody [EPR9923(B)] (ab168343)
        All lanes : Anti-DOK5 antibody [EPR9923(B)] (ab168343) at 1/10000 dilution

        Lane 1 : IM9 lysate
        Lane 2 : Human fetal brain lysate
        Lane 3 : Human fetal heart lysate

        Lysates/proteins at 10 µg per lane.

        Secondary
        All lanes : Goat anti-rabbit HRP at 1/2000 dilution

        Predicted band size: 35 kDa

      References

      ab168343 has not yet been referenced specifically in any publications.

      Publishing research using ab168343? Please let us know so that we can cite the reference in this datasheet.

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