Product nameDomiphen bromide, HERG channel inhibitor
DescriptionQuaternary ammonium antiseptic. Potent HERG channel inhibitor.
- (Dodecyldimethyl-2-phenoxyethyl)ammonium bromide
Quaternary ammonium antiseptic. Inhibits HERG (ether-a-go-go related gene) potassium channels in a dose-dependent manner (IC50 = 9nM).
Chemical nameDodecyldimethyl-(2-phenoxyethyl)azanium bromide
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in DMSO to 100 mM, in water to 100 mM and in ethanol to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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This product has been referenced in:
- Long Y et al. Inhibition of HERG potassium channels by domiphen bromide and didecyl dimethylammonium bromide. Eur J Pharmacol 737:202-9 (2014). Read more (PubMed: 24846011) »
- Gao P et al. Identification and validation of a novel lead compound targeting 4-diphosphocytidyl-2-C-methylerythritol synthetase (IspD) of mycobacteria. Eur J Pharmacol 694:45-52 (2012). Read more (PubMed: 22975264) »