Recombinant
RabMAb

Recombinant Anti-DOPA Decarboxylase/DDC antibody [EPR7851] (ab131282)

Overview

  • Product name

    Anti-DOPA Decarboxylase/DDC antibody [EPR7851]
    See all DOPA Decarboxylase/DDC primary antibodies
  • Description

    Rabbit monoclonal [EPR7851] to DOPA Decarboxylase/DDC
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
    Unsuitable for: Flow Cyt,ICC,IHC-P or IP
  • Species reactivity

    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide corresponding to Human DOPA Decarboxylase/DDC aa 1-100.
    Database link: P20711

  • Positive control

    • Human adrenal gland, 293T, RAW 264.7, and NIH 3T3 lysates.
  • General notes

     

     

    Previously labelled as DOPA Decarboxylase.

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents.

    This product is a recombinant rabbit monoclonal antibody.

Properties

Applications

Our Abpromise guarantee covers the use of ab131282 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/10000. Predicted molecular weight: 53 kDa.
  • Application notes
    Is unsuitable for Flow Cyt,ICC,IHC-P or IP.
  • Target

    • Function

      Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine.
    • Pathway

      Catecholamine biosynthesis; dopamine biosynthesis; dopamine from L-tyrosine: step 2/2.
    • Involvement in disease

      Defects in DDC are the cause of aromatic L-amino-acid decarboxylase deficiency (AADCD) [MIM:608643]. AADCD deficiency is an inborn error in neurotransmitter metabolism that leads to combined serotonin and catecholamine deficiency. It causes developmental and psychomotor delay, poor feeding, lethargy, ptosis, intermittent hypothermia, gastrointestinal disturbances. The onset is early in infancy and inheritance is autosomal recessive.
    • Sequence similarities

      Belongs to the group II decarboxylase family.
    • Information by UniProt
    • Database links

    • Alternative names

      • AADC antibody
      • Aromatic L Amino Acid Decarboxylase antibody
      • Aromatic-L-amino-acid decarboxylase antibody
      • DDC antibody
      • DDC_HUMAN antibody
      • DOPA decarboxylase (aromatic L-amino acid decarboxylase) antibody
      • DOPA decarboxylase antibody
      see all

    Images

    • All lanes : Anti-DOPA Decarboxylase/DDC antibody [EPR7851] (ab131282) at 1/1000 dilution

      Lane 1 : Human adrenal
      gland lysate
      Lane 2 : 293T lysate
      Lane 3 : RAW 264.7 lysate
      Lane 4 : NIH 3T3 lysate

      Lysates/proteins at 10 µg per lane.

      Secondary
      All lanes : HRP labelled goat anti-rabbit at 1/2000 dilution

      Predicted band size: 53 kDa

    • Equilibrium disassociation constant (KD)
      Learn more about KD

      Click here to learn more about KD

    References

    This product has been referenced in:

    • Pan JX  et al. Absence of gut microbiota during early life affects anxiolytic Behaviors and monoamine neurotransmitters system in the hippocampal of mice. J Neurol Sci 400:160-168 (2019). Read more (PubMed: 30954660) »
    • Bonsall DR  et al. Single cocaine exposure does not alter striatal pre-synaptic dopamine function in mice: an [18 F]-FDOPA PET study. J Neurochem 143:551-560 (2017). Read more (PubMed: 28921596) »
    See all 3 Publications for this product

    Customer reviews and Q&As

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    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
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