Key features and details
- Rabbit polyclonal to DOPA Decarboxylase/DDC - N-terminal
- Suitable for: IHC-P, WB
- Reacts with: Cow, Human
- Isotype: IgG
Product nameAnti-DOPA Decarboxylase/DDC antibody - N-terminal
See all DOPA Decarboxylase/DDC primary antibodies
DescriptionRabbit polyclonal to DOPA Decarboxylase/DDC - N-terminal
Tested applicationsSuitable for: IHC-P, WBmore details
Species reactivityReacts with: Cow, Human
Predicted to work with: Rat, Sheep, Guinea pig, Dog
Synthetic peptide corresponding to Human DOPA Decarboxylase/DDC (N terminal) conjugated to keyhole limpet haemocyanin. (NP_000781)
Database link: P20711
- Human caudate and bovine adrenal medulla lysates; Human kidney tissue.
Previously labelled as DOPA Decarboxylase.
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Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferpH: 7.50
Constituents: 0.87% Sodium chloride, 0.24% HEPES, 50% Glycerol, 0.01% BSA
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab189101 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-P||1/100. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.|
|WB||1/1000. Predicted molecular weight: 53 kDa.|
FunctionCatalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine.
PathwayCatecholamine biosynthesis; dopamine biosynthesis; dopamine from L-tyrosine: step 2/2.
Involvement in diseaseDefects in DDC are the cause of aromatic L-amino-acid decarboxylase deficiency (AADCD) [MIM:608643]. AADCD deficiency is an inborn error in neurotransmitter metabolism that leads to combined serotonin and catecholamine deficiency. It causes developmental and psychomotor delay, poor feeding, lethargy, ptosis, intermittent hypothermia, gastrointestinal disturbances. The onset is early in infancy and inheritance is autosomal recessive.
Sequence similaritiesBelongs to the group II decarboxylase family.
- Information by UniProt
- AADC antibody
- Aromatic L Amino Acid Decarboxylase antibody
- Aromatic-L-amino-acid decarboxylase antibody
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human kidney tissue labeling DOPA Decarboxylase/DDC with ab189101 at 1/100.
Anti-DOPA Decarboxylase/DDC antibody - N-terminal (ab189101) at 1/1000 dilution + Human caudate lysate at 20 µg
Predicted band size: 53 kDa
Anti-DOPA Decarboxylase/DDC antibody - N-terminal (ab189101) at 1/1000 dilution + Bovine adrenal medulla lysate at 5 µg
Predicted band size: 53 kDa
ab189101 has not yet been referenced specifically in any publications.