Key features and details
- Goat polyclonal to Dopamine beta Hydroxylase
- Suitable for: WB, IHC-P
- Reacts with: Human
- Isotype: IgG
Product nameAnti-Dopamine beta Hydroxylase antibody
See all Dopamine beta Hydroxylase primary antibodies
DescriptionGoat polyclonal to Dopamine beta Hydroxylase
Tested applicationsSuitable for: WB, IHC-Pmore details
Species reactivityReacts with: Human
Predicted to work with: Mouse, Rat, Rabbit, Horse, Chicken, Guinea pig, Hamster, Cow, Pig, Chimpanzee
- Human Adrenal tissue; Jurkat cell lysate.
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Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferpH: 7.30
Preservative: 0.02% Sodium azide
Constituents: 99% Tris buffered saline, 0.5% BSA
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab189991 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||Use a concentration of 1 - 3 µg/ml. Predicted molecular weight: 69 kDa.|
|IHC-P||Use a concentration of 5 µg/ml.|
FunctionConversion of dopamine to noradrenaline.
PathwayCatecholamine biosynthesis; (R)-noradrenaline biosynthesis; (R)-noradrenaline from dopamine: step 1/1.
Involvement in diseaseDefects in DBH are the cause of dopamine beta-hydroxylase deficiency (DBH deficiency) [MIM:223360]; also known as norepinephrine deficiency or noradrenaline deficiency. This disorder is characterized by profound deficits in autonomic and cardiovascular function, but apparently only subtle signs, if any, of central nervous system dysfunction.
Sequence similaritiesBelongs to the copper type II ascorbate-dependent monooxygenase family.
Contains 1 DOMON domain.
Cellular localizationCytoplasmic vesicle > secretory vesicle lumen. Cytoplasmic vesicle > secretory vesicle > chromaffin granule lumen and Cytoplasmic vesicle > secretory vesicle membrane. Cytoplasmic vesicle > secretory vesicle > chromaffin granule membrane.
- Information by UniProt
- dbh antibody
- DBM antibody
- Dopamine beta hydroxylase antibody
Anti-Dopamine beta Hydroxylase antibody (ab189991) at 2 µg/ml + Jurkat cell lysate (in RIPA buffer) at 35 µg
Developed using the ECL technique.
Predicted band size: 69 kDa
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human adrenal tissue labeling Dopamine beta Hydroxylase with ab189991 at 5 µg/ml.
ab189991 has been referenced in 1 publication.
- Konosu-Fukaya S et al. Catecholamine-Synthesizing Enzymes in Pheochromocytoma and Extraadrenal Paraganglioma. Endocr Pathol 29:302-309 (2018). PubMed: 30155766