Overview

  • Product name

    Anti-Dopamine D2 Receptor antibody - Cytoplasmic domain
    See all Dopamine D2 Receptor primary antibodies
  • Description

    Rabbit polyclonal to Dopamine D2 Receptor - Cytoplasmic domain
  • Host species

    Rabbit
  • Specificity

    BLAST analysis of the peptide immunogen showed no homology with other human proteins, except ZNF57 (42%).
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Rabbit, Horse, Cow, Dog, Pig, Chimpanzee, Monkey, Gorilla, Common marmoset
  • Immunogen

    Synthetic peptide corresponding to Human Dopamine D2 Receptor. (19 amino acid peptide from 3rd cytoplasmic domain).
    Database link: P14416

  • Positive control

    • Human brain tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab188612 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 5 - 10 µg/ml. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.

Target

  • Function

    This is one of the five types (D1 to D5) of receptors for dopamine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.
  • Involvement in disease

    Defects in DRD2 are associated with dystonia type 11 (DYT11) [MIM:159900]; also known as alcohol-responsive dystonia. DYT11 is a myoclonic dystonia. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. DYT11 is characterized by involuntary lightning jerks and dystonic movements and postures alleviated by alcohol. Inheritance is autosomal dominant. The age of onset, pattern of body involvement, presence of myoclonus and response to alcohol are all variable.
  • Sequence similarities

    Belongs to the G-protein coupled receptor 1 family.
  • Cellular localization

    Cell membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • D(2) dopamine receptor antibody
    • D2 dopamine receptor antibody
    • D2DR antibody
    • D2R antibody
    • Dopamine D2 receptor antibody
    • Dopamine receptor D2 antibody
    • DRD 2 antibody
    • DRD2 antibody
    • DRD2_HUMAN antibody
    see all

Images

  • Immunohistochemical analysis of formalin fixed, paraffin embedded human brain tissue labeling Dopamine Receptor D2L with ab188612 at 10 µg/ml.

References

ab188612 has not yet been referenced specifically in any publications.

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