Anti-Dopamine Receptor D3/DRD3 antibody (ab150543)
Key features and details
- Rabbit polyclonal to Dopamine Receptor D3/DRD3
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-Dopamine Receptor D3/DRD3 antibody
See all Dopamine Receptor D3/DRD3 primary antibodies -
Description
Rabbit polyclonal to Dopamine Receptor D3/DRD3 -
Host species
Rabbit -
Tested applications
Suitable for: IHC-Pmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Mouse, Rat, Rabbit, Horse, Hamster, Dog, Pig, Chimpanzee, Monkey, Common marmoset, Bat, Elephant -
Immunogen
Synthetic peptide corresponding to Human Dopamine Receptor D3/DRD3.
Database link: NP_000787.2 -
Positive control
- Human brain tissue (globus pallidus).
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
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Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. -
Storage buffer
pH: 7.4
Preservative: 0.1% Sodium azide
Constituent: 99% PBS -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab150543 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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IHC-P |
Use a concentration of 16 - 32 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
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Notes |
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IHC-P
Use a concentration of 16 - 32 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
Target
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Function
This is one of the five types (D1 to D5) of receptors for dopamine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation. -
Tissue specificity
Brain. -
Involvement in disease
Genetic variation in DRD3 is associated with essential tremor hereditary type 1 (ETM1) [MIM:190300]. ETM1 is the most common movement disorder. The main feature is postural tremor of the arms. Head, legs, trunk, voice, jaw, and facial muscles also may be involved. The condition can be aggravated by emotions, hunger, fatigue and temperature extremes, and may cause a functional disability or even incapacitation. Inheritance is autosomal dominant. -
Sequence similarities
Belongs to the G-protein coupled receptor 1 family. -
Post-translational
modificationsPhosphorylated by GRK4 (GRK4-alpha and GRK4-gamma). -
Cellular localization
Cell membrane. Both membrane-bound and scattered in the cytoplasm during basal conditions. Receptor stimulation results in the rapid internalization and sequestration of the receptors at the perinuclear area (5 and 15 minutes), followed by the dispersal of the receptors to the membrane (30 minutes). DRD3 and GRK4 co-localize in lipid rafts of renal proximal tubule cells. - Information by UniProt
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Database links
- Entrez Gene: 470885 Chimpanzee
- Entrez Gene: 487984 Dog
- Entrez Gene: 100061160 Horse
- Entrez Gene: 1814 Human
- Entrez Gene: 13490 Mouse
- Entrez Gene: 29238 Rat
- Omim: 126451 Human
- SwissProt: Q5IS72 Chimpanzee
see all -
Alternative names
- 3dopamine receptor antibody
- D antibody
- D(3) dopamine receptor antibody
see all
Images
Datasheets and documents
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SDS download
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Datasheet download
References (0)
ab150543 has not yet been referenced specifically in any publications.