Key features and details
- Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
- Rabbit monoclonal [EPR10148] to Dopamine Receptor D3/DRD3
- Suitable for: WB
- Reacts with: Mouse, Rat, Human
Product nameAnti-Dopamine Receptor D3/DRD3 antibody [EPR10148]
See all Dopamine Receptor D3/DRD3 primary antibodies
DescriptionRabbit monoclonal [EPR10148] to Dopamine Receptor D3/DRD3
Tested applicationsSuitable for: WBmore details
Unsuitable for: Flow Cyt,ICC,IHC-P or IP
Species reactivityReacts with: Mouse, Rat, Human
corresponding to Human Dopamine Receptor D3/DRD3.
Database link: P35462
- SH-SY5Y, Human fetal brain and Mouse brain lysates.
This product was previously labelled as Dopamine Receptor D3
This product is a recombinant monoclonal antibody, which offers several advantages including:
- - High batch-to-batch consistency and reproducibility
- - Improved sensitivity and specificity
- - Long-term security of supply
- - Animal-free production
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
Storage instructionsShipped at 4°C. Store at -20ºC.
Storage bufferPreservative: 0.01% Sodium azide
Constituents: 9% PBS, 40% Glycerol, 0.05% BSA, 50% Tissue culture supernatant
Concentration information loading...
PurityTissue culture supernatant
Our Abpromise guarantee covers the use of ab155098 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/1000 - 1/10000. Predicted molecular weight: 44 kDa.|
FunctionThis is one of the five types (D1 to D5) of receptors for dopamine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation.
Involvement in diseaseGenetic variation in DRD3 is associated with essential tremor hereditary type 1 (ETM1) [MIM:190300]. ETM1 is the most common movement disorder. The main feature is postural tremor of the arms. Head, legs, trunk, voice, jaw, and facial muscles also may be involved. The condition can be aggravated by emotions, hunger, fatigue and temperature extremes, and may cause a functional disability or even incapacitation. Inheritance is autosomal dominant.
Sequence similaritiesBelongs to the G-protein coupled receptor 1 family.
modificationsPhosphorylated by GRK4 (GRK4-alpha and GRK4-gamma).
Cellular localizationCell membrane. Both membrane-bound and scattered in the cytoplasm during basal conditions. Receptor stimulation results in the rapid internalization and sequestration of the receptors at the perinuclear area (5 and 15 minutes), followed by the dispersal of the receptors to the membrane (30 minutes). DRD3 and GRK4 co-localize in lipid rafts of renal proximal tubule cells.
- Information by UniProt
- 3dopamine receptor antibody
- D antibody
- D(3) dopamine receptor antibody
ab155098 has been referenced in 1 publication.
- Seo JH & Kuzhikandathil EV Dopamine D3 Receptor Mediates Preadolescent Stress-Induced Adult Psychiatric Disorders. PLoS One 10:e0143908 (2015). PubMed: 26619275