Dopamine Receptor D3/DRD3 peptide (ab128688)
Key features and details
- Purity: = 88% HPLC
- Suitable for: WB, Blocking
Description
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Product name
Dopamine Receptor D3/DRD3 peptide -
Purity
= 88 % HPLC.
Purified on a Reversed-Phase HPLC column and quality and characterized by mass spec. The purity of these peptides is checked by analytical HPLC and calculated by considering the area under the peptide peak as a percentage of areas under all peaks. -
Animal free
No -
Nature
Synthetic
Associated products
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Corresponding Antibody
Specifications
Our Abpromise guarantee covers the use of ab128688 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Applications
Western blot
Blocking - Blocking peptide for Anti-Dopamine Receptor D3/DRD3 antibody (ab42114)
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Form
Liquid -
Additional notes
This product was previously labelled as Dopamine Receptor D3
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Concentration information loading...
Preparation and Storage
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Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
General Info
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Alternative names
- 3dopamine receptor
- D
- D(3) dopamine receptor
see all -
Function
This is one of the five types (D1 to D5) of receptors for dopamine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation. -
Tissue specificity
Brain. -
Involvement in disease
Genetic variation in DRD3 is associated with essential tremor hereditary type 1 (ETM1) [MIM:190300]. ETM1 is the most common movement disorder. The main feature is postural tremor of the arms. Head, legs, trunk, voice, jaw, and facial muscles also may be involved. The condition can be aggravated by emotions, hunger, fatigue and temperature extremes, and may cause a functional disability or even incapacitation. Inheritance is autosomal dominant. -
Sequence similarities
Belongs to the G-protein coupled receptor 1 family. -
Post-translational
modificationsPhosphorylated by GRK4 (GRK4-alpha and GRK4-gamma). -
Cellular localization
Cell membrane. Both membrane-bound and scattered in the cytoplasm during basal conditions. Receptor stimulation results in the rapid internalization and sequestration of the receptors at the perinuclear area (5 and 15 minutes), followed by the dispersal of the receptors to the membrane (30 minutes). DRD3 and GRK4 co-localize in lipid rafts of renal proximal tubule cells. - Information by UniProt
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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Datasheet download
References (2)
ab128688 has been referenced in 2 publications.
- Kilic T et al. Mining the Potential of Label-Free Biosensors for In Vitro Antipsychotic Drug Screening. Biosensors (Basel) 8:N/A (2018). PubMed: 29315269
- Ustione A & Piston DW Dopamine synthesis and D3 receptor activation in pancreatic ß-cells regulates insulin secretion and intracellular [Ca(2+)] oscillations. Mol Endocrinol 26:1928-40 (2012). Blocking . PubMed: 22918877