Product nameDopamine Receptor D3/DRD3 peptide
Our Abpromise guarantee covers the use of ab128688 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Blocking - Blocking peptide for Anti-Dopamine Receptor D3/DRD3 antibody (ab42114)
This product was previously labelled as Dopamine Receptor D3
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
- 3dopamine receptor
- D(3) dopamine receptor
FunctionThis is one of the five types (D1 to D5) of receptors for dopamine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation.
Involvement in diseaseGenetic variation in DRD3 is associated with essential tremor hereditary type 1 (ETM1) [MIM:190300]. ETM1 is the most common movement disorder. The main feature is postural tremor of the arms. Head, legs, trunk, voice, jaw, and facial muscles also may be involved. The condition can be aggravated by emotions, hunger, fatigue and temperature extremes, and may cause a functional disability or even incapacitation. Inheritance is autosomal dominant.
Sequence similaritiesBelongs to the G-protein coupled receptor 1 family.
modificationsPhosphorylated by GRK4 (GRK4-alpha and GRK4-gamma).
Cellular localizationCell membrane. Both membrane-bound and scattered in the cytoplasm during basal conditions. Receptor stimulation results in the rapid internalization and sequestration of the receptors at the perinuclear area (5 and 15 minutes), followed by the dispersal of the receptors to the membrane (30 minutes). DRD3 and GRK4 co-localize in lipid rafts of renal proximal tubule cells.
- Information by UniProt
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab128688 has been referenced in 2 publications.
- Kilic T et al. Mining the Potential of Label-Free Biosensors for In Vitro Antipsychotic Drug Screening. Biosensors (Basel) 8:N/A (2018). PubMed: 29315269
- Ustione A & Piston DW Dopamine synthesis and D3 receptor activation in pancreatic ß-cells regulates insulin secretion and intracellular [Ca(2+)] oscillations. Mol Endocrinol 26:1928-40 (2012). Blocking . PubMed: 22918877