Anti-Dopamine Receptor D5 antibody, prediluted (ab32621)

Overview

  • Product name
    Anti-Dopamine Receptor D5 antibody, prediluted
    See all Dopamine Receptor D5 primary antibodies
  • Description
    Rabbit polyclonal to Dopamine Receptor D5, prediluted
  • Host species
    Rabbit
  • Tested applications
    Suitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Chicken
  • Immunogen

    Synthetic peptide within Human Dopamine Receptor D5 aa 450-550 (C terminal). The exact sequence is proprietary.

  • Positive control
    • Human brain tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab32621 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P
  • Application notes
    IHC-P: Use Neat for 30 min at room temperature. Staining of formalin fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0 for 10 min followed by cooling at room temperature for 20 min.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.
    • Tissue specificity
      Neuron-specific, localized primarily within limbic regions of the brain.
    • Involvement in disease
      Defects in DRD5 are a cause of benign essential blepharospasm (BEB) [MIM:606798]. BEB is a primary focal dystonia affecting the orbicularis oculi muscles. Dystonia is defined by the presence of sustained involuntary muscle contraction, often leading to abnormal postures. BEB usually begins in middle age. Initial symptoms include eye irritation and frequent blinking, progressing to involuntary spasms of eyelid closure. Patients have normal eyes. The visual disturbance is due solely to the forced closure of the eyelids. In severe cases, this can lead to functional blindness.
    • Sequence similarities
      Belongs to the G-protein coupled receptor 1 family.
    • Cellular localization
      Cell membrane.
    • Information by UniProt
    • Database links
    • Alternative names
      • D(1B) dopamine receptor antibody
      • D(5) dopamine receptor antibody
      • D1 beta dopamine receptor antibody
      • D1B dopamine receptor antibody
      • D1beta dopamine receptor antibody
      • D5 dopamine receptor antibody
      • DBDR antibody
      • Dopamine D5 receptor antibody
      • Dopamine receptor D1B antibody
      • dopamine receptor D5 antibody
      • DRD 1B antibody
      • DRD 5 antibody
      • DRD1B antibody
      • DRD1L2 antibody
      • DRD5 antibody
      • DRD5_HUMAN antibody
      • MGC10601 antibody
      see all

    Images

    • Ab32621, prediluted, staining Dopamine Receptor D5 in formalin fixed paraffin embedded human brain tissue sections by Immunohistochemistry.

    References

    ab32621 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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