Anti-Dopamine Transporter antibody (ab254059)
Key features and details
- Rabbit polyclonal to Dopamine Transporter
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-Dopamine Transporter antibody
See all Dopamine Transporter primary antibodies -
Description
Rabbit polyclonal to Dopamine Transporter -
Host species
Rabbit -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Mouse, Non human primates -
Immunogen
Synthetic peptide within Human Dopamine Transporter (C terminal) conjugated to keyhole limpet haemocyanin. The exact sequence is proprietary.
Database link: Q01959 -
Positive control
- WB: Human striatal lysate.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.50
Constituents: 0.24% HEPES, 0.87% Sodium chloride, 50% Glycerol, 10% BSA -
Concentration information loading...
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Purity
Immunogen affinity purified -
Purification notes
Prepared from pooled rabbit serum by affinity purification using a column matrix to which the peptide immunogen was coupled. -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab254059 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
---|---|---|
WB |
1/1000.
|
Notes |
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WB
1/1000. |
Target
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Function
Amine transporter. Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals. -
Involvement in disease
Defects in SLC6A3 are the cause of dystonia-parkinsonism infantile (DYTPRI) [MIM:613135]. It is a neurodegenerative disorder characterized by infantile onset of parkinsonism and dystonia. Other neurologic features include global developmental delay, bradikinesia and pyramidal tract signs. -
Sequence similarities
Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A3 subfamily. -
Cellular localization
Membrane. - Information by UniProt
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Database links
- Entrez Gene: 6531 Human
- Entrez Gene: 13162 Mouse
- Omim: 126455 Human
- SwissProt: Q01959 Human
- SwissProt: Q61327 Mouse
- Unigene: 406 Human
- Unigene: 41993 Mouse
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Alternative names
- DA transporter antibody
- DAT 1 antibody
- DAT antibody
see all
Images
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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SDS download
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Datasheet download
References (0)
ab254059 has not yet been referenced specifically in any publications.