- References (7)
Product nameDorsomorphin (Compound C)
DescriptionPotent, selective and reversible AMP-kinase inhibitor. Selective for BMP signaling.
- Compound C
Biological descriptionPotent, selective and reversible inhibitor of AMP-kinase (Ki = 109 nM). Inhibits AMPK activation induced by AICAR (ab120358) and metformin (ab120847). Selective inhibitor of bone morphogenetic protein (BMP) type I receptors (ALK2, ALK3 and ALK6). Does not affect ZAPK, SYK, PKCθ, PKA and JAK3. Cell-permeable.
Also available in a water soluble form (Dorsomorphin dihydrochloride - ab144821)
Storage instructionsStore at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in DMSO to 10 mM (with heating) and to ethanol to 5 mM (with heating)
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Please note that sonication in a 55 °C water bath is necessary for dissolution of ab120843 in DMSO to 10 mM.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
- Pathways and Processes
- Metabolic signaling pathways
- Energy transfer pathways
- Integration of energy
This product has been referenced in:
- Vucicevic L et al. Compound C induces protective autophagy in cancer cells through AMPK inhibition-independent blockade of Akt/mTOR pathway. Autophagy 7:40-50 (2011). Read more (PubMed: 20980833) »
- Kudo TA et al. Dorsomorphin stimulates neurite outgrowth in PC12 cells via activation of a protein kinase A-dependent MEK-ERK1/2 signaling pathway. Genes Cells 16:1121-32 (2011). Read more (PubMed: 21988724) »
- Zhou G et al. Role of AMP-activated protein kinase in mechanism of metformin action. J Clin Invest 108:1167-74 (2001). Read more (PubMed: 11602624) »