Dorsomorphin (Compound C), AMP-kinase inhibitor (ab120843)
Key features and details
- Potent, selective and reversible AMP-kinase inhibitor. Selective for BMP signaling.
- CAS Number: 866405-64-3
- Purity: > 99%
- Soluble in DMSO to 10 mM (with heating) and to ethanol to 5 mM (with heating)
- Form / State: Solid
- Source: Synthetic
Overview
-
Product name
Dorsomorphin (Compound C), AMP-kinase inhibitor -
Description
Potent, selective and reversible AMP-kinase inhibitor. Selective for BMP signaling. -
Alternative names
- Compound C
-
Biological description
Potent, selective and reversible inhibitor of AMP-kinase (Ki = 109 nM). Inhibits AMPK activation induced by AICAR (ab120358) and metformin (ab120847). Selective inhibitor of bone morphogenetic protein (BMP) type I receptors (ALK2, ALK3 and ALK6). Does not affect ZAPK, SYK, PKCθ, PKA and JAK3. Cell-permeable.
Also available in a water soluble form (Dorsomorphin dihydrochloride - ab144821) -
Purity
> 99% -
CAS Number
866405-64-3 -
Chemical structure
Properties
-
Chemical name
6-[4-[2-(1-Piperidinyl)ethoxy]phenyl]-3-(4-pyridinyl)pyrazolo[1,5-a]pyrimidine -
Molecular weight
399.49 -
Molecular formula
C24H25N5O -
PubChem identifier
11524144 -
Storage instructions
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 10 mM (with heating) and to ethanol to 5 mM (with heating) -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Please note that sonication in a 55 °C water bath is necessary for dissolution of ab120843 in DMSO to 10 mM.
Refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
-
SMILES
c1c(cnc2c(cnn12)c3ccncc3)c5ccc(OCCN4CCCCC4)cc5 -
Source
Synthetic
-
Research areas
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Lipid and lipoprotein metabolism
- Cholesterol Metabolism
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Lipid and lipoprotein metabolism
- Fatty acids
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Energy transfer pathways
- Energy Metabolism
Images
-
Chemical Structure - Dorsomorphin (Compound C), AMP-kinase inhibitor (ab120843)2D chemical structure image of ab120843, Dorsomorphin (Compound C), AMP-kinase inhibitor
-
Functional Studies - Dorsomorphin (Compound C), AMP-kinase inhibitor (ab120843)Li et al PLoS One. 2015 Sep 23;10(9):e0138390. doi: 10.1371/journal.pone.0138390. eCollection 2015. Fig 6. Reproduced under the Creative Commons license http://creativecommons.org/licenses/by/4.0/G9a inhibition induces autophagy and autophagic cell death through AMPK/mTOR pathway.
T24 cells (Panel G) and UMUC-3 cells (Panel H) were pre-treated with compound C (5 μM) or AICAR (1 mM) and then treated with BIX-01294 (1.5 μM) for 48 h, Cells viability was assessed by MTT assay. *P<0.01.
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
References (43)
ab120843 has been referenced in 43 publications.
- Wang K et al. Branched-chain amino acid aminotransferase 2 regulates ferroptotic cell death in cancer cells. Cell Death Differ 28:1222-1236 (2021). PubMed: 33097833
- Wang L et al. Adropin inhibits the phenotypic modulation and proliferation of vascular smooth muscle cells during neointimal hyperplasia by activating the AMPK/ACC signaling pathway. Exp Ther Med 21:560 (2021). PubMed: 33850532
- Sternlieb T et al. An AMP-activated protein kinase complex with two distinctive alpha subunits is involved in nutritional stress responses in Trypanosoma cruzi. PLoS Negl Trop Dis 15:e0009435 (2021). PubMed: 34029334
- Wegscheid ML et al. Patient-derived iPSC-cerebral organoid modeling of the 17q11.2 microdeletion syndrome establishes CRLF3 as a critical regulator of neurogenesis. Cell Rep 36:109315 (2021). PubMed: 34233200
- Shi Y & Hou SA Protective effects of metformin against myocardial ischemia-reperfusion injury via AMPK-dependent suppression of NOX4. Mol Med Rep 24:N/A (2021). PubMed: 34396450