Overview

  • Product name
    Dorsomorphin (Compound C) (DMSO solution)
  • Description
    Potent, selective and reversible AMP-kinase inhibitor. Selective for BMP signaling.
  • Biological description
    Potent, selective and reversible inhibitor of AMP-kinase (Ki = 109 nM). Inhibits AMPK activation induced by AICAR (ab120358) and metformin (ab120847). Selective inhibitor of bone morphogenetic protein (BMP) type I receptors (ALK2, ALK3 and ALK6). Does not affect ZAPK, SYK, PKCθ, PKA and JAK3. Cell-permeable.
    Also available in a water soluble form (dorsomorphin dihydrochloride - ab144821)

    Also available as a solid (ab120843).
  • Purity
    > 99%
  • General notes

    A natural process can cause the product to crystallize out of solution. Should it happen, it is advised to heat the solution to approximately 55°C and let it cool down before use.

Properties

  • Chemical name
    6-[4-[2-(1-Piperidinyl)ethoxy]phenyl]-3-(4-pyridinyl)pyrazolo[1,5-a]pyrimidine
  • Molecular weight
    399.49
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C24H25N5O
  • CAS Number
    866405-64-3
  • PubChem identifier
    11524144
  • Storage instructions
    Store at -20°C. Store In the Dark. Store under desiccating conditions. This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes.
  • Solubility overview
    Supplied in DMSO (10mM)
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    c1c(cnc2c(cnn12)c3ccncc3)c5ccc(OCCN4CCCCC4)cc5
  • Source

    Synthetic

References

ab146597 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab146597.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

Sign up