Dorsomorphin dihydrochloride, AMP-kinase inhibitor (ab144821)

Overview

  • Product name

    Dorsomorphin dihydrochloride, AMP-kinase inhibitor
  • Description

    Potent, selective, reversible AMP-kinase inhibitor. BMP type I receptor inhibitor.
  • Biological description

    Potent, selective, reversible AMP-kinase inhibitor (Ki = 109 nM). BMP type I receptor inhibitor. Induce autophagy in cancer cells independent of AMPK inhibition. Promotes cardiomyogenesis in embryonic stem cells. Reduces hepcidin, VCAM-1 and ICAM-1 expression in vivo.
  • Purity

    > 99%
  • CAS Number

    1219168-18-9
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Ali JL  et al. Differential cellular responses induced by dorsomorphin and LDN-193189 in chemotherapy-sensitive and chemotherapy-resistant human epithelial ovarian cancer cells. Int J Cancer 136:E455-69 (2015). Read more (PubMed: 25227893) »
  • Garulli C  et al. Dorsomorphin reverses the mesenchymal phenotype of breast cancer initiating cells by inhibition of bone morphogenetic protein signaling. Cell Signal 26:352-62 (2014). Read more (PubMed: 24280125) »
  • Yu PB  et al. Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism. Nat Chem Biol 4:33-41 (2008). Read more (PubMed: 18026094) »

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