Doxapram hydrochloride monohydrate, K+ channel blocker (ab142751)

Overview

  • Product name

    Doxapram hydrochloride monohydrate, K+ channel blocker
  • Description

    K+ channel blocker
  • Biological description

    K+ channel blocker. Stimulates dopamine release from carotid bodies and glial cells in brainstem slices. Respiratory system agent and CNS stimulant. Active in vitro and in vivo.
  • Purity

    > 98%
  • CAS Number

    7081-53-0
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    1-Ethyl-4-(2-morpholin-4-ylethyl)-3,3-diphenylpyrrolidin-2-one hydrochloride monohydrate
  • Molecular weight

    432.98
  • Molecular formula

    C24H30N2O2.HCl.H2O
  • PubChem identifier

    64648
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Toxic, refer to SDS for further information.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CCN1CC(C(C1=O)(C2=CC=CC=C2)C3=CC=CC=C3)CCN4CCOCC4.O.Cl
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Li GC  et al. Glial cells are involved in the exciting effects of doxapram on brainstem slices in vitro. Cell Mol Neurobiol 30:667-70 (2010). Read more (PubMed: 20140700) »
  • Anderson-Beck R  et al. Doxapram stimulates dopamine release from the intact rat carotid body in vitro. Neurosci Lett 187:25-8 (1995). Read more (PubMed: 7617294) »
  • Mitchell RA & Herbert DA Potencies of doxapram and hypoxia in stimulating carotid-body chemoreceptors and ventilation in anesthetized cats. Anesthesiology 42:559-66 (1975). Read more (PubMed: 1130721) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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