Key features and details
- Potent monoamine receptor antagonist and reuptake inhibitor
- CAS Number: 1229-29-4
- Purity: > 98%
- Soluble in 1 N HCl to 100 mM
- Form / State: Solid
- Source: Synthetic
Product nameDoxepin hydrochloride, monoamine receptor antagonist
DescriptionPotent monoamine receptor antagonist and reuptake inhibitor
Potent monoamine receptor antagonist and reuptake inhibitor (Ki values are 276, 26, 9, 136, 24, 1270, 38, 160, 52, 82, 75, 360, 0.2, 106, 68 and 30 nM for 5-HT1A, 5-HT2A, 5HT2C, 5-HT6, α1, α2, M1, M2, M3, M4, , D2, H1, H4, SERT and NET respectively). Shows antidepressant, anxiolytic, sedative and antipruritic effects in vivo. Orally active.
Chemical name(3E)-3-(6H-Benzo[c]benzoxepin-11-ylidene)-N,N-dimethylpropan-1-amine hydrochloride salt
Storage instructionsStore at Room Temperature. The product can be stored for up to 12 months.
Solubility overviewSoluble in 1 N HCl to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab143312 has not yet been referenced specifically in any publications.