Doxycycline hyclate, matrix metalloprotease inhibitor (ab141091)

Overview

  • Product name

    Doxycycline hyclate, matrix metalloprotease inhibitor
  • Description

    Synthetic tetracycline; matrix metalloprotease inhibitor
  • Biological description

    Synthetic tetracycline; matrix metalloprotease (MMP) inhibitor. Inhibits tumour growth, suppresses cell proliferation and induces apoptosis in vitro and in vivo.
  • Purity

    > 97%
  • CAS Number

    24390-14-5
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (4S,4aR,5S,5aR,6R,12aS)-4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide hyclate
  • Molecular weight

    512.94
  • Molecular formula

    C22H24N2O8.HCl.0.5C2H5OH.0.5H2O
  • PubChem identifier

    54686183
  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 100 mM and in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    Cl.Cl.O.CCO.NC(=O)C=3C(=O)[C@@]4(O)C(O)=C2C(=O)c1c(O)cccc1[C@H](C)[C@H]2[C@H](O)[C@H]4[C@H](N(C)C)C=3O.NC(=O)C=3C(=O)[C@@]4(O)C(O)=C2C(=O)c1c(O)cccc1[C@H](C)[C@H]2[C@H](O)[C@H]4[C@@H](C=3O)N(C)C
  • Source

    Synthetic

References

This product has been referenced in:

  • Walker NF  et al. Doxycycline and HIV infection suppress tuberculosis-induced matrix metalloproteinases. Am J Respir Crit Care Med 185:989-97 (2012). Read more (PubMed: 22345579) »
  • Fife RS & Sledge GW Effects of doxycycline on in vitro growth, migration, and gelatinase activity of breast carcinoma cells. J Lab Clin Med 125:407-11 (1995). Read more (PubMed: 7897308) »

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