Doxycycline monohydrate, Matrix metalloprotease (MMP) inhibitor (ab142865)

Overview

  • Product name

    Doxycycline monohydrate, Matrix metalloprotease (MMP) inhibitor
  • Description

    Cell-permeable antibiotic. MMP inhibitor.
  • Biological description

    Cell-permeable antibiotic. MMP inhibitor (IC50 values are 18 and 280 μM at MMP-8 and MMP-1 respectively). Oxytetracyline (ab143429) derivative. Shows anti-angiogenesis effects. Orally active.
  • Purity

    > 97%
  • CAS Number

    17086-28-1
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Su W  et al. Doxycycline-mediated inhibition of corneal angiogenesis: an MMP-independent mechanism. Invest Ophthalmol Vis Sci 54:783-8 (2013). Read more (PubMed: 23249709) »
  • Tobe R  et al. High error rates in selenocysteine insertion in mammalian cells treated with the antibiotic doxycycline, chloramphenicol, or geneticin. J Biol Chem 288:14709-15 (2013). Read more (PubMed: 23589299) »
  • Nowak E  et al. MMP-9 directed shRNAs as relevant inhibitors of matrix metalloproteinase 9 activity and signaling. Postepy Hig Med Dosw (Online) 67:742-9 (2013). Read more (PubMed: 24018440) »

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