Overview

  • Product name

  • Description

    Rabbit polyclonal to DP2
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-P, WBmore details
  • Species reactivity

    Reacts with: Mouse, Human
  • Immunogen

    Recombinant fragment corresponding to Human DP2 aa 344-386.
    Database link: Q14188

  • Positive control

    • WB: Mouse heart lysate; HeLa whole cell lysate. IHC-P: Human gastric cancer and kidney tissues.

Properties

Applications

Our Abpromise guarantee covers the use of ab235830 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/20 - 1/200.
WB 1/1000 - 1/5000. Predicted molecular weight: 49 kDa.

Target

  • Function

    Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DP2/E2F complex functions in the control of cell-cycle progression from G1 to S phase. The E2F-1/DP complex appears to mediate both cell proliferation and apoptosis.
  • Tissue specificity

    High levels in heart and skeletal muscle. Also found in placenta, kidney, brain, lung and liver. The presence as well as the abundance of the different transcripts appear to vary significantly in different tissues and cell lines.
  • Sequence similarities

    Belongs to the E2F/DP family.
  • Post-translational
    modifications

    Ser-24 is probably phosphorylated by CDK2.
  • Cellular localization

    Nucleus.
  • Information by UniProt
  • Database links

  • Alternative names

    • DP2 antibody
    • E2F dimerization partner 2 antibody
    • Tfdp2 antibody
    • TFDP2_HUMAN antibody
    • Transcription factor Dp 2 antibody
    • Transcription factor Dp-2 antibody
    see all

Images

  • All lanes : Anti-DP2 antibody (ab235830) at 1/1000 dilution

    Lane 1 : Mouse heart lysate
    Lane 2 : HeLa (human epithelial cell line from cervix adenocarcinoma) whole cell lysate

    Secondary
    All lanes : Goat polyclonal to rabbit IgG at 1/50000000 dilution

    Predicted band size: 49 kDa

  • Paraffin-embedded human gastric cancer tissue stained for DP2 using ab235830 at 1/100 dilution in immunohistochemical analysis.

  • Paraffin-embedded human kidney tissue stained for DP2 using ab235830 at 1/100 dilution in immunohistochemical analysis.

References

ab235830 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab235830.
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