Potent, selective ERβ agonist (EC50 values are 0.85 and 66 nM for ERβ and ERα, respectively). Cardioprotective and neuroprotective in vivo.
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Soluble in DMSO to 100 mM and in ethanol to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Morissette M et al. Contribution of estrogen receptors alpha and beta to the effects of estradiol in the brain. J Steroid Biochem Mol Biol108:327-38 (2008).
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Nikolic I et al. Treatment with an estrogen receptor-beta-selective agonist is cardioprotective. J Mol Cell Cardiol42:769-80 (2007).
Read more (PubMed: 17362982) »
Carswell HV et al. Neuroprotection by a selective estrogen receptor beta agonist in a mouse model of global ischemia. Am J Physiol Heart Circ Physiol287:H1501-4 (2004).
Read more (PubMed: 15155257) »
Meyers MJ et al. Estrogen receptor-beta potency-selective ligands: structure-activity relationship studies of diarylpropionitriles and their acetylene and polar analogues. J Med Chem44:4230-51 (2001).
Read more (PubMed: 11708925) »