Overview

  • Product name

    DPN, ERbeta agonist
  • Description

    Potent, selective ERβ agonist
  • Biological description

    Potent, selective ERβ agonist (EC50 values are 0.85 and 66 nM for ERβ and ERα, respectively). Cardioprotective and neuroprotective in vivo.
  • Purity

    > 99%
  • CAS Number

    1428-67-7
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Morissette M  et al. Contribution of estrogen receptors alpha and beta to the effects of estradiol in the brain. J Steroid Biochem Mol Biol 108:327-38 (2008). Read more (PubMed: 17936613) »
  • Nikolic I  et al. Treatment with an estrogen receptor-beta-selective agonist is cardioprotective. J Mol Cell Cardiol 42:769-80 (2007). Read more (PubMed: 17362982) »
  • Carswell HV  et al. Neuroprotection by a selective estrogen receptor beta agonist in a mouse model of global ischemia. Am J Physiol Heart Circ Physiol 287:H1501-4 (2004). Read more (PubMed: 15155257) »
  • Meyers MJ  et al. Estrogen receptor-beta potency-selective ligands: structure-activity relationship studies of diarylpropionitriles and their acetylene and polar analogues. J Med Chem 44:4230-51 (2001). Read more (PubMed: 11708925) »

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