Overview

  • Product name

    DPQ (DMSO solution), PARP-1 inhibitor
  • Description

    Potent, selective PARP-1 inhibitor
  • Biological description

    Potent, selective PARP-1 inhibitor (IC50 = 37 nM). Inhibits NF-κB signaling. Shows anti-inflammatory effects in vivo.

    Also available as a solid (ab141461).
  • Purity

    > 98%
  • CAS Number

    129075-73-6
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    5-(4-Piperidin-1-ylbutoxy)-3,4-dihydro-2H-isoquinolin-1-one
  • Molecular weight

    302.41
  • Molecular formula

    C18H26N2O2
  • PubChem identifier

    9948349
  • Storage instructions

    Store at -20°C. Store In the Dark. Store under desiccating conditions. This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes.
  • Solubility overview

    Supplied in DMSO (10 mM)
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1CCN(CC1)CCCCOC2=CC=CC3=C2CCNC3=O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Lechaftois M  et al. Another "string to the bow" of PJ34, a potent poly(ADP-Ribose)polymerase inhibitor: an antiplatelet effect through P2Y12 antagonism? PLoS One 9:e110776 (2014). Read more (PubMed: 25329809) »
  • Wang G  et al. PARP-1 inhibitor, DPQ, attenuates LPS-induced acute lung injury through inhibiting NF-?B-mediated inflammatory response. PLoS One 8:e79757 (2013). Read more (PubMed: 24278171) »
  • Tan C  et al. Differences in structure, physiological stability, electrochemistry, cytotoxicity, DNA and protein binding properties between two Ru(III) complexes. J Inorg Biochem 102:347-58 (2008). Read more (PubMed: 18022241) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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