Overview

  • Product name

    DPQ, PARP-1 inhibitor
  • Description

    Potent, selective PARP-1 inhibitor
  • Biological description

    Potent, selective PARP-1 inhibitor (IC50 = 37 nM). Also availbable as a DMSO solution (ab146611). Inhibits NF-κB signaling in macrophages. Shows anti-inflammatory, anti-ischemic and antiapoptotic effects in vivo.
  • Purity

    > 99%
  • CAS Number

    129075-73-6
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Wang J  et al. Inhibition of poly (ADP-ribose) polymerase and inducible nitric oxide synthase protects against ischemic myocardial damage by reduction of apoptosis. Mol Med Rep 11:1768-76 (2015). Read more (PubMed: 25412407) »
  • Scalia M  et al. PARP-1 inhibitors DPQ and PJ-34 negatively modulate proinflammatory commitment of human glioblastoma cells. Neurochem Res 38:50-8 (2013). Read more (PubMed: 23011206) »
  • Wang G  et al. PARP-1 inhibitor, DPQ, attenuates LPS-induced acute lung injury through inhibiting NF-?B-mediated inflammatory response. PLoS One 8:e79757 (2013). Read more (PubMed: 24278171) »
  • del Moral RM  et al. PARP inhibition attenuates histopathological lesion in ischemia/reperfusion renal mouse model after cold prolonged ischemia. ScientificWorldJournal 2013:486574 (2013). Read more (PubMed: 24319370) »
  • Mizuguchi H  et al. Involvement of protein kinase Cdelta/extracellular signal-regulated kinase/poly(ADP-ribose) polymerase-1 (PARP-1) signaling pathway in histamine-induced up-regulation of histamine H1 receptor gene expression in HeLa cells. J Biol Chem 286:30542-51 (2011). Read more (PubMed: 21730054) »
  • Putt KS & Hergenrother PJ An enzymatic assay for poly(ADP-ribose) polymerase-1 (PARP-1) via the chemical quantitation of NAD(+): application to the high-throughput screening of small molecules as potential inhibitors. Anal Biochem 326:78-86 (2004). Read more (PubMed: 14769338) »
  • Moroni F  et al. Poly(ADP-ribose) polymerase inhibitors attenuate necrotic but not apoptotic neuronal death in experimental models of cerebral ischemia. Cell Death Differ 8:921-32 (2001). Read more (PubMed: 11526447) »
See 1 Publication for this product

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