Overview

  • Product name

  • Description

    Rabbit polyclonal to DPYS
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, IHC-Pmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Recombinant fragment corresponding to Human DPYS aa 122-276.
    Sequence:

    DPKVCCDYS LHVAVTWWSD QVKEEMKILV QDKGVNSFKM FMAYKDLYMV TDLELYEAFS RCKEIGAIAQ VHAENGDLIA EGAKKMLALG ITGPEGHELC RPEAVEAEAT LRAITIASAV NCPLYIVHVM SKSAAKVIAD ARRDGKVVYG EPIAAS


    Database link: Q14117

  • Positive control

    • Human fetal liver lysate. Human fetal pancreas tissue.
  • General notes

    Previously labelled as Dihydropyrimidinase.

Properties

  • Form

    Lyophilised:Reconstitute in 200 µL sterile H2O.
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer

    pH: 7.20
    Preservative: 0.02% Sodium azide
    Constituents: 1% BSA, 98% PBS
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab205039 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/200 - 1/1000. Predicted molecular weight: 57 kDa.
IHC-P 1/100 - 1/500.

Target

  • Function

    Catalyzes the second step of the reductive pyrimidine degradation, the reversible hydrolytic ring opening of dihydropyrimidines. Can catalyzes the ring opening of 5,6-dihydrouracil to N-carbamyl-alanine and of 5,6-dihydrothymine to N-carbamyl-amino isobutyrate.
  • Tissue specificity

    Liver and kidney.
  • Involvement in disease

    Defects in DPYS are the cause of dihydropyrimidinase deficiency (DHPD) [MIM:222748]. DHPD is an autosomal recessive disorder characterized by dihydropyrimidinuria and associated with a variable clinical phenotype: epileptic or convulsive attacks, dysmorphic features and severe developmental delay, and congenital microvillous atrophy.
  • Sequence similarities

    Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily.
  • Post-translational
    modifications

    Carbamylation allows a single lysine to coordinate two zinc ions.
  • Information by UniProt
  • Database links

  • Alternative names

    • DHP antibody
    • DHPase antibody
    • Dihydropyrimidinase antibody
    • Dihydropyrimidine amidohydrolase antibody
    • Dpys antibody
    • DPYS_HUMAN antibody
    • Hydantoinase antibody
    see all

Images

  • Anti-DPYS antibody (ab205039) at 1/500 dilution + human fetal liver lysate

    Predicted band size: 57 kDa

  • Immunohistochemical analysis of formalin/PFA-fixed paraffin-embedded human fetal pancreas tissue sections labeling DPYS with ab205039 at a 1/100 dilution.

References

ab205039 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab205039.
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