• Product name

  • Description

    Rabbit polyclonal to DR3/LARD
  • Host species

  • Tested applications

    Suitable for: IHC-P, WBmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Synthetic peptide within Human DR3/LARD aa 370-417 conjugated to keyhole limpet haemocyanin. The exact sequence is proprietary.


    Database link: Q93038

  • Positive control

    • Human colon carcinoma lysate; Human colon tissue.
  • General notes

     This product was previously labelled as DR3




Our Abpromise guarantee covers the use of ab216658 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/100 - 1/500.
WB 1/100 - 1/1000. Detects a band of approximately 43 kDa (predicted molecular weight: 45 kDa).


  • Function

    Receptor for TNFSF12/APO3L/TWEAK. Interacts directly with the adapter TRADD. Mediates activation of NF-kappa-B and induces apoptosis. May play a role in regulating lymphocyte homeostasis.
  • Tissue specificity

    Abundantly expressed in thymocytes and lymphocytes. Detected in lymphocyte-rich tissues such as thymus, colon, intestine, and spleen. Also found in the prostate.
  • Sequence similarities

    Contains 1 death domain.
    Contains 4 TNFR-Cys repeats.
  • Post-translational

  • Cellular localization

    Secreted and Cell membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • Apo 3 antibody
    • Apo-3 antibody
    • Apo3 antibody
    • Apoptosis inducing receptor AIR antibody
    • Apoptosis inducing receptor antibody
    • Apoptosis mediating receptor antibody
    • Apoptosis mediating receptor DR 3 antibody
    • Apoptosis mediating receptor DR3 antibody
    • Apoptosis mediating receptor TRAMP antibody
    • Apoptosis-inducing receptor AIR antibody
    • Apoptosis-mediating receptor DR3 antibody
    • Apoptosis-mediating receptor TRAMP antibody
    • DDR 3 antibody
    • DDR3 antibody
    • Death domain receptor 3 antibody
    • Death domain receptor 3 soluble form antibody
    • Death receptor 3 antibody
    • Death receptor beta antibody
    • DR 3 antibody
    • DR3 antibody
    • LARD antibody
    • Lymphocyte associated receptor of death antibody
    • Lymphocyte-associated receptor of death antibody
    • Protein WSL antibody
    • Protein WSL-1 antibody
    • TNF receptor superfamily member 25 antibody
    • TNFR25 antibody
    • TNFRSF 12 antibody
    • TNFRSF 25 antibody
    • TNFRSF12 antibody
    • TNFRSF12, formerly antibody
    • TNFRSF25 antibody
    • TNR25_HUMAN antibody
    • TR 3 antibody
    • TR3 antibody
    • TRAMP antibody
    • Translocating chain association membrane protein antibody
    • Tumor necrosis factor receptor superfamily member 12 antibody
    • Tumor necrosis factor receptor superfamily member 25 antibody
    • Tumor necrosis factor receptor superfamily, member 12 (translocating chain association membrane protein) antibody
    • Tumor necrosis factor receptor superfamily, member 12, formerly antibody
    • WSL 1 antibody
    • WSL antibody
    • WSL LR antibody
    • WSL protein antibody
    • WSL1 antibody
    • WSL1 protein antibody
    • WSLLR antibody
    see all


  • Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human colon tissue labeling DR3/LARD with ab216658 at 1/200 dilution, followed by conjugation to the secondary antibody and DAB staining.

  • All lanes : Anti-DR3/LARD antibody (ab216658) at 1/200 dilution

    Lane 1 : Human colon carcinoma lysate
    Lane 2 : Rat brain lysate

    All lanes : Goat anti-rabbit IgG (H+L), HRP conjugated at 1/3000 dilution

    Predicted band size: 45 kDa
    Observed band size: 43 kDa
    why is the actual band size different from the predicted?

    12% gel


ab216658 has not yet been referenced specifically in any publications.

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