Anti-DR3/LARD antibody [JD3] (ab234187)

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Key features and details

  • Mouse monoclonal [JD3] to DR3/LARD
  • Suitable for: Flow Cyt
  • Reacts with: Human
  • Isotype: IgG1

Overview

  • Product name

    Anti-DR3/LARD antibody [JD3]
    See all DR3/LARD primary antibodies

  • Description

    Mouse monoclonal [JD3] to DR3/LARD

  • Host species

    Mouse

  • Tested applications

    Suitable for: Flow Cytmore details

  • Species reactivity

    Reacts with: Human

  • Immunogen

    Fusion protein corresponding to Human DR3/LARD.
    Database link: Q93038

  • Positive control

    • Flow Cytometry: DR3/LARD-transfected HEK-293 cells.

  • General notes

     This product was previously labelled as DR3

     

    Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.

    Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.

    We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.

    In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.

    We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.

    Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.

    Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.

Properties

Applications

Our Abpromise guarantee covers the use of ab234187 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt Use at an assay dependent concentration.

Target

  • Function

    Receptor for TNFSF12/APO3L/TWEAK. Interacts directly with the adapter TRADD. Mediates activation of NF-kappa-B and induces apoptosis. May play a role in regulating lymphocyte homeostasis.

  • Tissue specificity

    Abundantly expressed in thymocytes and lymphocytes. Detected in lymphocyte-rich tissues such as thymus, colon, intestine, and spleen. Also found in the prostate.

  • Sequence similarities

    Contains 1 death domain.
    Contains 4 TNFR-Cys repeats.

  • Post-translational
    modifications

    Glycosylated.

  • Cellular localization

    Secreted and Cell membrane.
  • Information by UniProt

  • Database links

    • Alternative names

      • Apo 3 antibody
      • Apo-3 antibody
      • Apo3 antibody
      • Apoptosis inducing receptor AIR antibody
      • Apoptosis inducing receptor antibody
      • Apoptosis mediating receptor antibody
      • Apoptosis mediating receptor DR 3 antibody
      • Apoptosis mediating receptor DR3 antibody
      • Apoptosis mediating receptor TRAMP antibody
      • Apoptosis-inducing receptor AIR antibody
      • Apoptosis-mediating receptor DR3 antibody
      • Apoptosis-mediating receptor TRAMP antibody
      • DDR 3 antibody
      • DDR3 antibody
      • Death domain receptor 3 antibody
      • Death domain receptor 3 soluble form antibody
      • Death receptor 3 antibody
      • Death receptor beta antibody
      • DR 3 antibody
      • DR3 antibody
      • LARD antibody
      • Lymphocyte associated receptor of death antibody
      • Lymphocyte-associated receptor of death antibody
      • Protein WSL antibody
      • Protein WSL-1 antibody
      • TNF receptor superfamily member 25 antibody
      • TNFR25 antibody
      • TNFRSF 12 antibody
      • TNFRSF 25 antibody
      • TNFRSF12 antibody
      • TNFRSF12, formerly antibody
      • TNFRSF25 antibody
      • TNR25_HUMAN antibody
      • TR 3 antibody
      • TR3 antibody
      • TRAMP antibody
      • Translocating chain association membrane protein antibody
      • Tumor necrosis factor receptor superfamily member 12 antibody
      • Tumor necrosis factor receptor superfamily member 25 antibody
      • Tumor necrosis factor receptor superfamily, member 12 (translocating chain association membrane protein) antibody
      • Tumor necrosis factor receptor superfamily, member 12, formerly antibody
      • WSL 1 antibody
      • WSL antibody
      • WSL LR antibody
      • WSL protein antibody
      • WSL1 antibody
      • WSL1 protein antibody
      • WSLLR antibody
      see all

    Images

    • Flow Cytometry - Anti-DR3/LARD antibody [JD3] (ab234187)
      Flow Cytometry - Anti-DR3/LARD antibody [JD3] (ab234187)

      Flow cytometric analysis of DR3/LARD-transfected (red) and non-transfected HEK-293 (human epithelial cell line from embryonic kidney) (black) cells labeling DR3/LARD with ab234187.

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    References (1)

    Publishing research using ab234187? Please let us know so that we can cite the reference in this datasheet.

    ab234187 has been referenced in 1 publication.

    • Cavallini C  et al. The TNF-family cytokine TL1A inhibits proliferation of human activated B cells. PLoS One 8:e60136 (2013). PubMed: 23565196

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