Anti-DR5 antibody [DR5-01-1] (Phycoerythrin) (ab55863)

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Overview

  • Product name

    Anti-DR5 antibody [DR5-01-1] (Phycoerythrin)
    See all DR5 primary antibodies

  • Description

    Mouse monoclonal [DR5-01-1] to DR5 (Phycoerythrin)

  • Host species

    Mouse

  • Conjugation

    Phycoerythrin. Ex: 488nm, Em: 575nm

  • Specificity

    This recognizes an extracellular domain of TRAIL R2 (DR5).

  • Tested applications

    Suitable for: Flow Cytmore details

  • Species reactivity

    Reacts with: Human

  • Immunogen

    Recombinant fusion protein of human IgG heavy chain and an extracellular domain of DR5 (TRAIL R2) (Human).

  • Positive control

    • JURKAT human peripheral blood leukemia T cell line.

Properties

Applications

Our Abpromise guarantee covers the use of ab55863 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt
  • Application notes
    Flow Cyt: Use at a concentration of 5.0 µg/ml. This dilution is a recommended starting point for use of this product. Working concentrations should be determined by the end user.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.

    • Target

    • Function

      Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis.

    • Tissue specificity

      Widely expressed in adult and fetal tissues; very highly expressed in tumor cell lines such as HeLaS3, K-562, HL-60, SW480, A-549 and G-361; highly expressed in heart, peripheral blood lymphocytes, liver, pancreas, spleen, thymus, prostate, ovary, uterus, placenta, testis, esophagus, stomach and throughout the intestinal tract; not detectable in brain.

    • Involvement in disease

      Squamous cell carcinoma of the head and neck

    • Sequence similarities

      Contains 1 death domain.
      Contains 3 TNFR-Cys repeats.

    • Cellular localization

      Membrane.
    • Information by UniProt

    • Database links

      • Alternative names

        • Fas like protein antibody
        • Apoptosis inducing protein TRICK2A/2B antibody
        • Apoptosis inducing receptor TRAIL R2 antibody
        • CD262 antibody
        • CD262 antigen antibody
        • Cytotoxic TRAIL receptor 2 antibody
        • Death domain containing receptor for TRAIL/Apo 2L antibody
        • Death receptor 5 antibody
        • DR5 antibody
        • KILLER antibody
        • KILLER/DR5 antibody
        • OTTHUMP00000123492 antibody
        • OTTHUMP00000123493 antibody
        • p53 regulated DNA damage inducible cell death receptor(killer) antibody
        • TNF related apoptosis inducing ligand receptor 2 antibody
        • TNF-related apoptosis-inducing ligand receptor 2 antibody
        • TNFRSF10B antibody
        • TR10B_HUMAN antibody
        • TRAIL R2 antibody
        • TRAIL receptor 2 antibody
        • TRAIL-R2 antibody
        • TRAILR2 antibody
        • TRICK2 antibody
        • TRICK2A antibody
        • TRICK2B antibody
        • TRICKB antibody
        • Tumor necrosis factor receptor like protein ZTNFR9 antibody
        • Tumor necrosis factor receptor superfamily member 10B antibody
        • Tumor necrosis factor receptor superfamily, member 10b antibody
        • ZTNFR9 antibody
        see all

      References

      This product has been referenced in:

      • Masum AA  et al. Luminescent Iridium Complex-Peptide Hybrids (IPHs) for Therapeutics of Cancer: Design and Synthesis of IPHs for Detection of Cancer Cells and Induction of Their Necrosis-Type Cell Death. Bioinorg Chem Appl 2018:7578965 (2018). Read more (PubMed: 30154833) »
      See 1 Publication for this product

      Publishing research using ab55863? Please let us know so that we can cite the reference in this datasheet.

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