Anti-DR5 antibody [DR5-01-1] (Phycoerythrin) (ab55863)
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Overview
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Product nameAnti-DR5 antibody [DR5-01-1] (Phycoerythrin)
See all DR5 primary antibodies -
DescriptionMouse monoclonal [DR5-01-1] to DR5 (Phycoerythrin)
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Host speciesMouse
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ConjugationPhycoerythrin. Ex: 488nm, Em: 575nm
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SpecificityThis recognizes an extracellular domain of TRAIL R2 (DR5).
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Tested applicationsSuitable for: Flow Cytmore details
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Species reactivityReacts with: Human
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Immunogen
Recombinant fusion protein of human IgG heavy chain and an extracellular domain of DR5 (TRAIL R2) (Human).
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Positive control
- JURKAT human peripheral blood leukemia T cell line.
Properties
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FormLiquid
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Storage instructionsShipped at 4°C. Store at +4°C.
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Storage bufferPreservative: 0.097% Sodium azide
Constituent: 0.2% BSA
0.2% high grade; protease free BSA -
Concentration information loading... -
PuritySize exclusion
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ClonalityMonoclonal
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Clone numberDR5-01-1
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IsotypeIgG1
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Research areas
Associated products
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Alternative Versions
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Compatible Secondaries
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Isotype control
Applications
Our Abpromise guarantee covers the use of ab55863 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| Flow Cyt |
Application notes
Flow Cyt: Use at a concentration of 5.0 µg/ml. This dilution is a recommended starting point for use of this product. Working concentrations should be determined by the end user.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Target
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FunctionReceptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis.
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Tissue specificityWidely expressed in adult and fetal tissues; very highly expressed in tumor cell lines such as HeLaS3, K-562, HL-60, SW480, A-549 and G-361; highly expressed in heart, peripheral blood lymphocytes, liver, pancreas, spleen, thymus, prostate, ovary, uterus, placenta, testis, esophagus, stomach and throughout the intestinal tract; not detectable in brain.
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Involvement in diseaseSquamous cell carcinoma of the head and neck
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Sequence similaritiesContains 1 death domain.
Contains 3 TNFR-Cys repeats. -
Cellular localizationMembrane.
- Information by UniProt
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Database links
- Entrez Gene: 8795 Human
- Omim: 603612 Human
- SwissProt: O14763 Human
- Unigene: 521456 Human
- Unigene: 661668 Human
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Alternative names
- Fas like protein antibody
- Apoptosis inducing protein TRICK2A/2B antibody
- Apoptosis inducing receptor TRAIL R2 antibody
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Protocols
References
ab55863 has not yet been referenced specifically in any publications.
