Anti-DR5 antibody [DR5-01-1] (Phycoerythrin) (ab55863)

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Overview

  • Product name
    Anti-DR5 antibody [DR5-01-1] (Phycoerythrin)
    See all DR5 primary antibodies
  • Description
    Mouse monoclonal [DR5-01-1] to DR5 (Phycoerythrin)
  • Host species
    Mouse
  • Conjugation
    Phycoerythrin. Ex: 488nm, Em: 575nm
  • Specificity
    This recognizes an extracellular domain of TRAIL R2 (DR5).
  • Tested applications
    Suitable for: Flow Cytmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fusion protein of human IgG heavy chain and an extracellular domain of DR5 (TRAIL R2) (Human).

  • Positive control
    • JURKAT human peripheral blood leukemia T cell line.

Properties

Applications

Our Abpromise guarantee covers the use of ab55863 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt
  • Application notes
    Flow Cyt: Use at a concentration of 5.0 µg/ml. This dilution is a recommended starting point for use of this product. Working concentrations should be determined by the end user.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.

    • Target

    • Function
      Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis.
    • Tissue specificity
      Widely expressed in adult and fetal tissues; very highly expressed in tumor cell lines such as HeLaS3, K-562, HL-60, SW480, A-549 and G-361; highly expressed in heart, peripheral blood lymphocytes, liver, pancreas, spleen, thymus, prostate, ovary, uterus, placenta, testis, esophagus, stomach and throughout the intestinal tract; not detectable in brain.
    • Involvement in disease
      Squamous cell carcinoma of the head and neck
    • Sequence similarities
      Contains 1 death domain.
      Contains 3 TNFR-Cys repeats.
    • Cellular localization
      Membrane.
    • Information by UniProt
    • Database links
      • Alternative names
        • Fas like protein antibody
        • Apoptosis inducing protein TRICK2A/2B antibody
        • Apoptosis inducing receptor TRAIL R2 antibody
        • CD262 antibody
        • CD262 antigen antibody
        • Cytotoxic TRAIL receptor 2 antibody
        • Death domain containing receptor for TRAIL/Apo 2L antibody
        • Death receptor 5 antibody
        • DR5 antibody
        • KILLER antibody
        • KILLER/DR5 antibody
        • OTTHUMP00000123492 antibody
        • OTTHUMP00000123493 antibody
        • p53 regulated DNA damage inducible cell death receptor(killer) antibody
        • TNF related apoptosis inducing ligand receptor 2 antibody
        • TNF-related apoptosis-inducing ligand receptor 2 antibody
        • TNFRSF10B antibody
        • TR10B_HUMAN antibody
        • TRAIL R2 antibody
        • TRAIL receptor 2 antibody
        • TRAIL-R2 antibody
        • TRAILR2 antibody
        • TRICK2 antibody
        • TRICK2A antibody
        • TRICK2B antibody
        • TRICKB antibody
        • Tumor necrosis factor receptor like protein ZTNFR9 antibody
        • Tumor necrosis factor receptor superfamily member 10B antibody
        • Tumor necrosis factor receptor superfamily, member 10b antibody
        • ZTNFR9 antibody
        see all

      References

      ab55863 has not yet been referenced specifically in any publications.

      Publishing research using ab55863? Please let us know so that we can cite the reference in this datasheet.

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