Key features and details
- Rabbit polyclonal to DR6
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
Product nameAnti-DR6 antibody
See all DR6 primary antibodies
DescriptionRabbit polyclonal to DR6
Tested applicationsSuitable for: IHC-Pmore details
Species reactivityReacts with: Human
Predicted to work with: Mouse, Rat
Fusion protein corresponding to Human DR6 (internal sequence). (BC010241). The identity of the protein fusion partner is GST.
Database link: O75509
- Human thyroid cancer and Human brain tissues.
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferpH: 7.30
Preservative: 0.05% Sodium azide
Constituents: 50% Glycerol, 49% PBS
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab198034 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-P||1/20 - 1/100.|
FunctionMay activate NF-kappa-B and promote apoptosis. May activate JNK and be involved in T-cell differentiation. Required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6).
Tissue specificityHighly expressed in heart, brain, placenta, pancreas, lymph node, thymus and prostate. Detected at lower levels in lung, skeletal muscle, kidney, testis, uterus, small intestine, colon, spleen, bone marrow and fetal liver. Very low levels were found in adult liver and peripheral blood leukocytes.
Sequence similaritiesContains 1 death domain.
Contains 4 TNFR-Cys repeats.
- Information by UniProt
- TNFRSF 21 antibody
- BM 018 antibody
- BM018 antibody
ab198034 has not yet been referenced specifically in any publications.