Overview

  • Product name

  • Description

    Rabbit polyclonal to Draxin
  • Host species

    Rabbit
  • Specificity

    At least three isoforms of Draxin are known to exist; ab117452 will detect the two shorter isoforms. ab117452 is predicted to not cross-react with RILP.

  • Tested applications

    Suitable for: ICC/IF, WB, IHC-P, ICCmore details
  • Species reactivity

    Reacts with: Mouse, Rat
    Predicted to work with: Human
  • Immunogen

    Synthetic peptide corresponding to Human Draxin (C terminal). (BAG80561)

  • Positive control

    • Rat cerebellum tissue lysate.
  • General notes

    Avoid repeated freeze thaw cycles and exposure to prolonged high temperatures.

Properties

Applications

Our Abpromise guarantee covers the use of ab117452 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF Use a concentration of 20 µg/ml.
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 38 kDa.
IHC-P Use at an assay dependent concentration.
ICC Use a concentration of 5 µg/ml.

Target

  • Function

    Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway.
  • Sequence similarities

    Belongs to the draxin family.
  • Cellular localization

    Secreted.
  • Information by UniProt
  • Database links

  • Alternative names

    • AGPA3119 antibody
    • Chromosome 1 open reading frame 187 antibody
    • Dorsal inhibitory axon guidance protein antibody
    • Dorsal repulsive axon guidance protein antibody
    • DRAXI_HUMAN antibody
    • Draxin antibody
    • FLJ34999 antibody
    • MGC117222 antibody
    • Neucrin antibody
    • OTTHUMP00000002262 antibody
    • UNQ3119 antibody
    see all

Images

  • Immunofluorescence of Draxin in mouse brain tissue with ab117452 at 20 ug/mL.

  • Anti-Draxin antibody (ab117452) at 1 µg/ml + Rat cerebellum tissue lysate at 15 µg

    Predicted band size: 38 kDa

  • Immunohistochemical analysis of mouse brain tissue, staining Draxin with ab117452 at 5 µg/ml.

References

ab117452 has not yet been referenced specifically in any publications.

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There are currently no Customer reviews or Questions for ab117452.
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