Overview

  • Product name

    DRB (Benzimidazole), Casein kinase II inhibitor
  • Description

    Casein kinase II inhibitor
  • Alternative names

    • Benzimidazole
    • DiCl-RB
    • NSC 401575
  • Biological description

    Casein kinase II inhibitor (Ki values are 23 and 48 μM for CKII and CKI, respectively). Inhibitor of RNA polymerase II transcription in vitro and in vivo. Shown to inhibit cyclin C/CDK8 (IC50 = 17 μM) and cyclin H/CDK7/p38 (IC50 = 18 μM) signaling.
  • Purity

    > 98%
  • CAS Number

    53-85-0
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Ye ZY  et al. Protein kinase CK2 increases glutamatergic input in the hypothalamus and sympathetic vasomotor tone in hypertension. J Neurosci 31:8271-9 (2011). Read more (PubMed: 21632948) »
  • Rickert P  et al. Cyclin C/CDK8 and cyclin H/CDK7/p36 are biochemically distinct CTD kinases. Oncogene 18:1093-102 (1999). Read more (PubMed: 10023686) »
  • Meggio F  et al. Ribofuranosyl-benzimidazole derivatives as inhibitors of casein kinase-2 and casein kinase-1. Eur J Biochem 187:89-94 (1990). Read more (PubMed: 2105215) »
See 1 Publication for this product

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