Key features and details
- Casein kinase II inhibitor
- CAS Number: 53-85-0
- Purity: > 98%
- Soluble in DMSO to 25 mM
- Form / State: Solid
- Source: Synthetic
Product nameDRB (Benzimidazole), Casein kinase II inhibitor
DescriptionCasein kinase II inhibitor
- NSC 401575
Biological descriptionCasein kinase II inhibitor (Ki values are 23 and 48 μM for CKII and CKI, respectively). Inhibitor of RNA polymerase II transcription in vitro and in vivo. Shown to inhibit cyclin C/CDK8 (IC50 = 17 μM) and cyclin H/CDK7/p38 (IC50 = 18 μM) signaling.
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in DMSO to 25 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab120939 has been referenced in 2 publications.
- Lu JY et al. Genomic Repeats Categorize Genes with Distinct Functions for Orchestrated Regulation. Cell Rep 30:3296-3311.e5 (2020). PubMed: 32160538
- Faust TB et al. The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation. Elife 7:N/A (2018). PubMed: 29845934