Overview

  • Product name

    Anti-DRD5 antibody - C-terminal
    See all DRD5 primary antibodies
  • Description

    Rabbit polyclonal to DRD5 - C-terminal
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Mouse, Rat
  • Immunogen

    Synthetic peptide corresponding to Mouse DRD5 aa 388-407 (C terminal).
    Sequence:

    LISYNQDTVFHREIAAAYVH


    Database link: Q8BLD9

  • Positive control

    • WB: Rat and mouse brain tissue lysates
  • General notes

     This product was previously labelled as Dopamine Receptor D5

     

Properties

Applications

Our Abpromise guarantee covers the use of ab181623 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.1 - 0.5 µg/ml. Predicted molecular weight: 53 kDa.

Target

  • Function

    Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.
  • Tissue specificity

    Neuron-specific, localized primarily within limbic regions of the brain.
  • Involvement in disease

    Defects in DRD5 are a cause of benign essential blepharospasm (BEB) [MIM:606798]. BEB is a primary focal dystonia affecting the orbicularis oculi muscles. Dystonia is defined by the presence of sustained involuntary muscle contraction, often leading to abnormal postures. BEB usually begins in middle age. Initial symptoms include eye irritation and frequent blinking, progressing to involuntary spasms of eyelid closure. Patients have normal eyes. The visual disturbance is due solely to the forced closure of the eyelids. In severe cases, this can lead to functional blindness.
  • Sequence similarities

    Belongs to the G-protein coupled receptor 1 family.
  • Cellular localization

    Cell membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • D(1B) dopamine receptor antibody
    • D(5) dopamine receptor antibody
    • D1 beta dopamine receptor antibody
    • D1B dopamine receptor antibody
    • D1beta dopamine receptor antibody
    • D5 dopamine receptor antibody
    • DBDR antibody
    • Dopamine D5 receptor antibody
    • Dopamine receptor D1B antibody
    • dopamine receptor D5 antibody
    • DRD 1B antibody
    • DRD 5 antibody
    • DRD1B antibody
    • DRD1L2 antibody
    • DRD5 antibody
    • DRD5_HUMAN antibody
    • MGC10601 antibody
    see all

Images

  • All lanes : Anti-DRD5 antibody - C-terminal (ab181623) at 0.5 µg

    Lane 1 : rat brain tissue
    Lane 2 : mouse brain tissue

    Lysates/proteins at 50 µg per lane.

    Secondary
    All lanes : Goat anti-rabbit IgG-HRP at 1/10000 dilution

    Developed using the ECL technique.

    Performed under reducing conditions.

    Predicted band size: 53 kDa

References

ab181623 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab181623.
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