Overview

  • Product name

    Droloxifene citrate, estrogen receptor antagonist
  • Description

    Estrogen receptor antagonist
  • Biological description

    Estrogen receptor antagonist. 10-fold greater binding affinity to the estrogen receptor than tamoxifen (ab120656). Inhibits growth of ER-positive tumor cells. Orally active. Antitumor agent. Active in vitro and in vivo.
  • Purity

    > 98%
  • CAS Number

    97752-20-0
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    3-[(E)-1-[4-[2-(Dimethylamino)ethoxy]phenyl]-2-phenylbut-1-enyl]phenol citrate
  • Molecular weight

    579.64
  • Molecular formula

    C26H29NO2.C6H8O7
  • PubChem identifier

    3033766
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in ethanol
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CCC(=C(C1=CC=C(C=C1)OCCN(C)C)C2=CC(=CC=C2)O)C3=CC=CC=C3.C(C(=O)O)C(CC(=O)O)(C(=O)O)O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Huang Y  et al. Anti-implantation effect of droloxifene in rats and its relationship with anti-estrogenic activity. Acta Pharmacol Sin 26:1243-7 (2005). Read more (PubMed: 16174441) »
  • Eppenberger U  et al. Pharmacologic and biologic properties of droloxifene, a new antiestrogen. Am J Clin Oncol 14 Suppl 2:S5-14 (1991). Read more (PubMed: 1962598) »
  • Kawamura I  et al. Antiestrogenic and antitumor effects of droloxifene in experimental breast carcinoma. Arzneimittelforschung 39:889-93 (1989). Read more (PubMed: 2818677) »

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