Droxidopa (L-DOPS), adrenergic receptor agonist (ab143354)

Overview

  • Product name

    Droxidopa (L-DOPS), adrenergic receptor agonist
  • Description

    Blood-brain barrier permeable prodrug to noradrenaline and adrenaline
  • Biological description

    Blood-brain barrier permeable prodrug to noradrenaline (ab120717) and adrenaline (ab142299). Improves hemodynamic and renal alterations in cirrhosis without changing portal pressure. Shows sympathomimetic and antiparkinsonian effects in vivo. Orally active.
  • Purity

    > 99%
  • CAS Number

    23651-95-8
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (2S,3R)-2-Amino-3-(3,4-dihydroxyphenyl)-3-hydroxypropanoic acid
  • Molecular weight

    213.19
  • Molecular formula

    C9H11NO5
  • PubChem identifier

    92974
  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 10 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1(=C(C=CC(=C1)[C@@H](O)[C@H](N)C(=O)O)O)O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Rodríguez S  et al. The renal effects of droxidopa are maintained in propranolol treated cirrhotic rats. Liver Int : (2014). Read more (PubMed: 24517276) »
  • Coll M  et al. Droxidopa, an oral norepinephrine precursor, improves hemodynamic and renal alterations of portal hypertensive rats. Hepatology 56:1849-60 (2012). Read more (PubMed: 22610782) »
  • Ikemoto K [Human striatal D-neurons and their significance]. Nihon Shinkei Seishin Yakurigaku Zasshi 22:131-5 (2002). Read more (PubMed: 12373866) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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