Overview

  • Product name

    Droxinostat, HDAC3, HDAC6 and HDAC8 inhibitor
  • Description

    Selective HDAC3, HDAC6 and HDAC8 inhibitor
  • Biological description

    Selective HDAC3, HDAC6 and HDAC8 inhibitor (IC50 values are 16.9, 2.47 and 1.46 μM for HDAC3, 6 and 8 respectively). Induces apoptosis. Shows antitumor effects in vivo.
  • Purity

    > 96%
  • CAS Number

    99873-43-5
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • McCourt C  et al. Elevation of c-FLIP in castrate-resistant prostate cancer antagonizes therapeutic response to androgen receptor-targeted therapy. Clin Cancer Res 18:3822-33 (2012). Read more (PubMed: 22623731) »
  • Wood TE  et al. Selective inhibition of histone deacetylases sensitizes malignant cells to death receptor ligands. Mol Cancer Ther 9:246-56 (2010). Read more (PubMed: 20053768) »
  • Mawji IA  et al. Critical role for Fas-associated death domain-like interleukin-1-converting enzyme-like inhibitory protein in anoikis resistance and distant tumor formation. J Natl Cancer Inst 99:811-22 (2007). Read more (PubMed: 17505076) »

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