• Product name

    Anti-DSPP antibody
  • Description

    Rabbit polyclonal to DSPP
  • Host species

  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Synthetic peptide. This information is considered to be commercially sensitive.

  • Positive control

    • Human laryngocarcinoma tissue



Our Abpromise guarantee covers the use of ab216892 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/100 - 1/500.


  • Function

    DSP may be an important factor in dentinogenesis. DPP may bind high amount of calcium and facilitate initial mineralization of dentin matrix collagen as well as regulate the size and shape of the crystals.
  • Tissue specificity

    Expressed in teeth. DPP is synthesized by odontoblast and transiently expressed by pre-ameloblasts.
  • Involvement in disease

    Defects in DSPP are the cause of deafness autosomal dominant type 39 with dentinogenesis imperfecta 1 (DFNA39/DGI1) [MIM:605594]. Affected individuals present DGI1 associated with early onset progressive sensorineural high-frequency hearing loss.
    Defects in DSPP are the cause of dentinogenesis imperfecta type 1 (DGI1) [MIM:125490]; also known as dentinogenesis imperfecta Shields type 2 (DGI2). DGI1 is an autosomal dominant disorder in which both the primary and the permanent teeth are affected. It occurs with an incidence of 1:8000 live births. The teeth are amber and opalescent, the pulp chamber being obliterated by abnormal dentin. The enamel, although unaffected, tends to fracture, which makes dentin undergo rapid attrition, leading to shortening of the teeth.
    Defects in DSPP are a cause of dentinogenesis imperfecta Shields type 3 (DGI3) [MIM:125500]. Patients with DGI3 do not have stigmata of osteogenesis imperfecta. The finding that a single defects in the DSPP gene causes both phenotypic patterns of DGI2 and DGI3 strongly supports the conclusion that these two disorders are not separate diseases but rather the phenotypic variation of a single genetic defect.
    Defects in DSPP are the cause of dentin dysplasia type 2 (DTDP2) [MIM:125420]; also known as dentin dysplasia Shields type 2. DTDP2 is an autosomal dominant disorder in which mineralization of the dentine of the primary teeth is abnormal. On the basis of the phenotypic overlap between, and shared chromosomal location with DGI2 it has been proposed that DTDP2 and DGI2 are allelic. From the results of recent studies, it is clear that different types of mutations in DSPP lead to the two different phenotypes.
  • Post-translational

    DSP is glycosylated.
  • Cellular localization

    Secreted > extracellular space > extracellular matrix.
  • Information by UniProt
  • Database links

  • Alternative names

    • Dentin phosphophoryn antibody
    • Dentin phosphoprotein antibody
    • dentin phosphoryn antibody
    • Dentin sialophosphoprotein antibody
    • Dentin sialophosphoprotein precursor antibody
    • Dentin sialoprotein antibody
    • dentinogenesis imperfecta 1 antibody
    • DFNA39 antibody
    • DGI1 antibody
    • DMP3 antibody
    • DPP antibody
    • DSP antibody
    • Dspp antibody
    • DSPP_HUMAN antibody
    • DTDP2 antibody
    see all


  • Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human laryngocarcinoma tissue labeling DSPP with ab216892 at 1/200 dilution, followed by conjugation to the secondary antibody and DAB staining.


This product has been referenced in:

  • Guo T  et al. Cbfa1 hinders autophagy by DSPP upregulation in odontoblast differentiation. Int J Biochem Cell Biol 115:105578 (2019). Read more (PubMed: 31374250) »
  • Huang X  et al. Rho/Rho-associated protein kinase signaling pathway-mediated downregulation of runt-related transcription factor 2 expression promotes the differentiation of dental pulp stem cells into odontoblasts. Exp Ther Med 15:4457-4464 (2018). Read more (PubMed: 29731830) »
See all 5 Publications for this product

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