Overview

  • Product name

  • Description

    Rabbit polyclonal to DTX1
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Mouse, Human
  • Immunogen

    Synthetic peptide corresponding to Human DTX1 (internal sequence). NP_004407.
    Database link: Q86Y01

  • Positive control

    • Human cervical cancer tissue and Human thyroid cancer tissue.
  • General notes

    Previously labelled as Deltex.

Properties

Applications

Our Abpromise guarantee covers the use of ab198877 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/25 - 1/100.

Target

  • Function

    Functions as a ubiquitin ligase protein in vivo, mediating ubiquitination and promoting degradation of MEKK1, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity (By similarity). Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Mainly acts as a positive regulator of Notch, but it also acts as a negative regulator, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Involved in neurogenesis, lymphogenesis and myogenesis, and may also be involved in MZB (Marginal zone B) cell differentiation. Promotes B-cell development at the expense of T-cell development, suggesting that it can antagonize NOTCH1.
  • Tissue specificity

    Widely expressed. Strongly expressed in blood vessel. Also expressed in embryonic nervous system, pancreas, lung, adrenal gland, digestive tube and muscles. Expressed in MZB cells and developing B- and T-cells.
  • Pathway

    Protein modification; protein ubiquitination.
  • Sequence similarities

    Belongs to the Deltex family.
    Contains 1 RING-type zinc finger.
    Contains 2 WWE domains.
  • Domain

    The WWE domains are thought to mediate some protein-protein interaction, and are frequently found in ubiquitin ligases.
  • Post-translational
    modifications

    Ubiquitinated; undergoes 'Lys-29'-linked polyubiquitination catalyzed by ITCH.
  • Cellular localization

    Cytoplasm. Nucleus. Predominantly cytoplasmic. Associates with endocytic vesicles. Partially nuclear.
  • Information by UniProt
  • Database links

  • Alternative names

    • Deltex 1, E3 ubiquitin ligase antibody
    • Deltex antibody
    • Deltex homolog 1 (Drosophila) antibody
    • Deltex homolog 1 antibody
    • Deltex protein 1 antibody
    • Deltex-1 antibody
    • Deltex1 antibody
    • dtx1 antibody
    • DTX1_HUMAN antibody
    • E3 ubiquitin protein ligase DTX1 antibody
    • E3 ubiquitin-protein ligase DTX1 antibody
    • FXI-T1 antibody
    • Fxit 1 antibody
    • Fxit1 antibody
    • hDTX1 antibody
    • hDx 1 antibody
    • mDTX1 antibody
    • Protein deltex 1 antibody
    • Protein deltex-1 antibody
    see all

Images

  • Immunohistochemical analysis of paraffin-embedded Human cervical cancer tissue labeling DTX1 with ab198877 at 1/30 dilution.

  • Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue labeling DTX-1 with ab198877 at 1/30 dilution.

References

ab198877 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab198877.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
For licensing inquiries, please contact partnerships@abcam.com

Sign up