Dutasteride, dual 5alpha reductase type 1 and type 2 inhibitor (ab141278)

Overview

  • Product name

    Dutasteride, dual 5alpha reductase type 1 and type 2 inhibitor
  • Description

    Selective, competitive dual 5α reductase type 1 and type 2 inhibitor
  • Biological description

    Selective, competitive dual 5α reductase type 1 and type 2 inhibitor. Blocks the conversion of testosterone into dihydrotestosterone. Shows antitumor effects in vivo. Orally active.
  • Purity

    > 99%
  • CAS Number

    164656-23-9
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (4aR,4bS,6aS,7S,9aS,9bS,11aR)-N-[2,5-Bis(trifluoromethyl)phenyl]-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-
    4a,6a-dimethyl-2-oxo-1H-Indeno[5,4-f]quinoline-7-carboxamide
  • Molecular weight

    528.53
  • Molecular formula

    C27H30F6N2O2
  • PubChem identifier

    6918296
  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM and in ethanol to 50 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    FC(F)(F)c5cc(NC(=O)[C@H]4CC[C@@H]3[C@]4(C)CC[C@H]1[C@H]3CC[C@H]2NC(=O)C=C[C@]12C)c(cc5)C(F)(F)F
  • Source

    Synthetic

References

This product has been referenced in:

  • Tsujimura A  et al. Histologic evaluation of human benign prostatic hyperplasia treated by dutasteride: a study by xenograft model with improved severe combined immunodeficient mice. Urology 85:274.e1-8 (2015). Read more (PubMed: 25444635) »
  • Wang D  et al. Effects of the 5a-reductase inhibitor dutasteride on rat prostate a1A-adrenergic receptor and its mediated contractility. Urology 85:704.e9-14 (2015). Read more (PubMed: 25733305) »
  • Yamana K  et al. Human type 3 5a-reductase is expressed in peripheral tissues at higher levels than types 1 and 2 and its activity is potently inhibited by finasteride and dutasteride. Horm Mol Biol Clin Investig 2:293-9 (2010). Read more (PubMed: 25961201) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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