Overview

  • Product name

    Anti-Dynamin 2 antibody [3F5C7]
    See all Dynamin 2 primary antibodies
  • Description

    Mouse monoclonal [3F5C7] to Dynamin 2
  • Host species

    Mouse
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Recombinant fragment corresponding to Human Dynamin 2 aa 520-744. (Expressed in E.coli).
    Database link: P50570

  • Positive control

    • WB: Recombinant human Dynamin 2 (aa 520-744) protein; Dynamin 2 (aa 520-744)-hIgGFc transfected HEK-293 cell lysate; U-251 MG, HeLa and K562 cell lysates.

Properties

Applications

Our Abpromise guarantee covers the use of ab233732 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/2000. Predicted molecular weight: 98 kDa.

Target

  • Function

    Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes, in particular endocytosis.
  • Tissue specificity

    Ubiquitously expressed.
  • Involvement in disease

    Defects in DNM2 are a cause of centronuclear myopathy autosomal dominant (ADCNM) [MIM:160150]; also known as autosomal dominant myotubular myopathy. Centronuclear myopathies (CNMs) are congenital muscle disorders characterized by progressive muscular weakness and wasting involving mainly limb girdle, trunk, and neck muscles. It may also affect distal muscles. Weakness may be present during childhood or adolescence or may not become evident until the third decade of life. Ptosis is a frequent clinical feature. CNMs comprise a wide spectrum of phenotypes, ranging from severe neonatal to mild late-onset familial forms. The most prominent histopathologic features include high frequency of centrally located nuclei in muscle fibers not secondary to regeneration, radial arrangement of sarcoplasmic strands around the central nuclei, and predominance and hypotrophy of type 1 fibers.
    Defects in DNM2 are the cause of Charcot-Marie-Tooth disease dominant intermediate type B (CMTDIB) [MIM:606482]. Charcot-Marie-Tooth disease (CMT) is a clinically and genetically heterogeneous disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. CMTDIB is a form of Charcot-Marie-Tooth disease characterized by clinical and pathologic features intermediate between demyelinating and axonal peripheral neuropathies, and motor median nerve conduction velocities ranging from 25 to 45 m/sec.
  • Sequence similarities

    Belongs to the dynamin family.
    Contains 1 GED domain.
    Contains 1 PH domain.
  • Cellular localization

    Cytoplasm. Cytoplasm > cytoskeleton. Cell junction > synapse > postsynaptic cell membrane > postsynaptic density. Cell junction > synapse. Microtubule-associated. Also found in the postsynaptic density of neuronal cells.
  • Information by UniProt
  • Database links

  • Alternative names

    • CMT2M antibody
    • CMTDI1 antibody
    • CMTDIB antibody
    • DI CMTB antibody
    • Dnm2 antibody
    • DYN II antibody
    • DYN2 antibody
    • DYN2_HUMAN antibody
    • Dynamin II antibody
    • Dynamin-2 antibody
    • Dynamin2 antibody
    • DynaminII antibody
    • DYNII antibody
    see all

Images

  • All lanes : Anti-Dynamin 2 antibody [3F5C7] (ab233732) at 1/500 dilution

    Lane 1 : U-251 MG (Human brain glioma cell line) cell lysate
    Lane 2 : HeLa (Human epithelial cell line from cervix adenocarcinoma) cell lysate
    Lane 3 : K562 (Human chronic myelogenous leukemia cell line from bone marrow) cell lysate

    Predicted band size: 98 kDa

  • All lanes : Anti-Dynamin 2 antibody [3F5C7] (ab233732) at 1/500 dilution

    Lane 1 : HEK-293 (human epithelial cell line from embryonic kidney) cell lysate
    Lane 2 : Dynamin 2 (aa 520-744)-hIgGFc transfected HEK-293 cell lysate

    Predicted band size: 98 kDa

  • Anti-Dynamin 2 antibody [3F5C7] (ab233732) at 1/500 dilution + Recombinant human Dynamin 2 (aa 520-744) protein

    Predicted band size: 98 kDa



    Expected MW is 28 kDa.

References

ab233732 has not yet been referenced specifically in any publications.

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