Anti-DYNC1H1 antibody (ab99500)

This fast track antibody is not yet fully characterized. It is subject to these terms and conditions.

Overview

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage buffer

    Preservative: 0.02% Sodium Azide
    Constituents: 0.5% BSA, Tris buffered saline, pH 7.3
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Purification notes

    Ammonium sulphate precipitation followed by antigen affinity chromatography.
  • Clonality

    Polyclonal
  • Isotype

    IgG

Target

  • Relevance

    Dyneins are a group of microtubule-activated ATPases that function as molecular motors. They are divided into two subgroups of axonemal and cytoplasmic dyneins. The cytoplasmic dyneins function in intracellular motility, including retrograde axonal transport, protein sorting, organelle movement, and spindle dynamics. Molecules of conventional cytoplasmic dynein are comprised of 2 heavy chain polypeptides and a number of intermediate and light chains. DYNC1H1 is a member of the cytoplasmic dynein heavy chain family which serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits.
  • Cellular localization

    Cytoplasmic, Golgi Apparatus, Microtubule.
  • Database links

  • Alternative names

    • cytoplasmic dynein 1 heavy chain 1 antibody
    • cytoplasmic dynein heavy chain 1 antibody
    • DHC1 antibody
    • DHC1a antibody
    • DKFZp686P2245 antibody
    • DNCH1 antibody
    • Dnchc1 antibody
    • DNECL antibody
    • DYHC antibody
    • dynein heavy chain, cytosolic antibody
    • dynein, cytoplasmic 1, heavy chain 1 antibody
    • dynein, cytoplasmic-like antibody
    • HL-3 antibody
    • KIAA0325 antibody
    • p22 antibody
    see all

References

ab99500 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

1-2 of 2 Abreviews or Q&A

Answer



These antibodies have not been tested specifically against the other form of dynein, however we have aligned the immunogen sequences against the amino acid sequences of each dynein, and there is no significant similarity to the alternative form. The immunogen of ab99500 only shows significant similarity with DYNC1H1, and ab122525 only shows similarity with DYNC2H1.

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Answer

Thank you for contacting us.

You are right; we usually state tested application, dilution range etc. on our datasheet. In addition, we try to give application tips and provide the expected molecular weight if WB was tested.

However, checking this datasheet, we state that this antibody is a "FAST TRACK antibody. It has been affinity purified and shows high titre values against the immunizing peptide by ELISA. " Therefore, we cannot tell you if it has been tested for WB or ICC as we simply don't know in this case.

From our Terms of Use which can be found on our datasheet:

"Fast-Track antibodies

Our customers have told us that they want cutting-edge products released quickly so that their research is not impeded. Abcam is therefore pleased to be able to offer researchers access to products that are still in development.

Fast-Track antibodies constitute a diverse group of products that have undergone variable degrees of characterization. They have all been affinity purified and show high titre values against the immunizing peptide (by ELISA).

As a general rule, Fast-Track antibodies fall into two main categories:
- Cutting-edge products: these are released quickly to meet customer needs and requirements; the products are still undergoing further tests and characterization steps
- Products which are more complex to characterize due to low levels/lack of expression in easily available lysates or problems experienced in searching for or developing the correct lysate/cell line


For these reasons, we release Fast-Track antibodies at a reduced price under the following terms:
- As these antibodies have not been fully characterized at Abcam, we cannot guarantee that the antibody will work in any application other than ELISA against the immunizing peptide and they are therefore not covered by the full Abpromise guarantee
- Our experienced Scientific Support Team is happy to offer protocol tips and advice to help improve the results obtained
- Whenever possible, Abcam will also make available data provided by customers that have bought a Fast-Track antibody, the information provided should be used as a guideline only


Feedback reward
We would greatly appreciate your feedback on these antibodies, whether positive or negative. We will award 950 bonus Abpoints to the first researcher who sends us positive feedback (including an image and details of materials and methods). Conclusive negative feedback that leads us to withdraw the antibody will also be rewarded with 950 bonus Abpoints. Other useful positive and negative feedback will be rewarded with the standard Abpoints for submitting an Abreview (please refer to Abreviews terms and conditions for more detailed information). All awards are subject to approval by Abcam scientists and provision of suitable data. Please submit feedback to fast-track@abcam.com"



I hope this information is helpful to you. Please do not hesitate to contact us if you need any more advice or information.

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
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