Recombinant Anti-Dynein axonemal intermediate chain antibody [EPR11222-78] (ab169758)
Key features and details
- Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
- Rabbit monoclonal [EPR11222-78] to Dynein axonemal intermediate chain
- Suitable for: WB
- Reacts with: Human
Related conjugates and formulations
Overview
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Product name
Anti-Dynein axonemal intermediate chain antibody [EPR11222-78]
See all Dynein axonemal intermediate chain primary antibodies -
Description
Rabbit monoclonal [EPR11222-78] to Dynein axonemal intermediate chain -
Host species
Rabbit -
Tested applications
Suitable for: WBmore details
Unsuitable for: ICC/IF,IHC-P or IP -
Species reactivity
Reacts with: Human
Predicted to work with: Mouse, Rat -
Immunogen
Recombinant fragment corresponding to Human Dynein axonemal intermediate chain.
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Positive control
- Fetal brain lysate; Human hypothalamus lysate.
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General notes
This product is a recombinant monoclonal antibody, which offers several advantages including:
- - High batch-to-batch consistency and reproducibility
- - Improved sensitivity and specificity
- - Long-term security of supply
- - Animal-free production
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. -
Storage buffer
pH: 7.2
Preservative: 0.01% Sodium azide
Constituents: 9% PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, 50% Tissue culture supernatant -
Concentration information loading...
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Purity
Tissue culture supernatant -
Clonality
Monoclonal -
Clone number
EPR11222-78 -
Isotype
IgG -
Research areas
Associated products
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Alternative Versions
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Isotype control
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Related Products
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab169758 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
1/1000 - 1/10000. Predicted molecular weight: 73 kDa.
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Notes |
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WB
1/1000 - 1/10000. Predicted molecular weight: 73 kDa. |
Target
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Function
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCNT1. May play a role in mediating the interaction of cytoplasmic dynein with membranous organelles and kinetochores. -
Sequence similarities
Belongs to the dynein intermediate chain family.
Contains 7 WD repeats. -
Cellular localization
Cytoplasm. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle pole. - Information by UniProt
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Database links
- Entrez Gene: 1780 Human
- Entrez Gene: 13426 Mouse
- Entrez Gene: 29564 Rat
- Omim: 603772 Human
- SwissProt: O14576 Human
- SwissProt: O88485 Mouse
- SwissProt: Q63100 Rat
- Unigene: 440364 Human
see all -
Alternative names
- Cytoplasmic dynein 1 intermediate chain 1 antibody
- Cytoplasmic dynein intermediate chain 1 antibody
- cytosolic antibody
see all
Images
Datasheets and documents
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SDS download
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Datasheet download
References (1)
ab169758 has been referenced in 1 publication.
- Liu YM et al. CircCCNB1 silencing acting as a miR-106b-5p sponge inhibited GPM6A expression to promote HCC progression by enhancing DYNC1I1 expression and activating the AKT/ERK signaling pathway. Int J Biol Sci 18:637-651 (2022). PubMed: 35002514