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I have purchased dynasore and dyngo 4a from you along with the dynamin toolkit containing iminodyn, dynole and MAB series compounds. The dynamin tool kit compounds contain infomation regarding dynamin binding sites but this information is not available for dynasore nor dyngo. I was wondering if you had any idea about the binding sites in dynamin 2 for these compounds or know of someone who may have an idea?
Asked on Jun 28 2012
Thank you for your enquiry.
Please find information about the biological activity of these compounds below. We also have specific references listed on the datasheet that will provide more information. Reviewing the online literature I have also found additional information.
Cell permeable dynamin inhibitor, that blocks endocytosis. Non-competitively inhibits dynamin1, dynamin2 and mitochondrial dynamin GTPase activity. Selective over other small GTPases.
Dynasore, a Dynamin Inhibitor, Inhibits Trypanosoma cruzi Entry into Peritoneal Macrophages
Novel, highly potent dynamin inhibitor (IC50 values are 380 nM and 2.6 µM at dynamin I and II respectively). Dynasore (ab120192) analogue. Prevents botulin neurotoxin A (BoNTs) uptake and internalisation, and prevents SNAP25 cleavage. Inhibits BoNTs induced paralysis and delays botulism onset.
Ascent Scientific Launch Novel Dynamin Inhibitor Dyngo-4a™ with Children's Medical Research Institute and University of Newcastle
I would suggest browsing other online resources that may have additional specific information. I hope this information helps.
Answered on Jun 28 2012