• Product name

  • Description

    Rabbit polyclonal to Dynorphin B
  • Host species

  • Specificity

    This antibody blocks specifically with Dynorphin B 1-13. Cells are found in the paraventricular hypothalamic and the supraoptic nucleus in rat brain of colchicine treated 4% FA perfused tissue. Fibers are found in the lateral hypothalamus of both colchicine and normal rat brain of 4% FA perfused tissue.
  • Tested applications

    Suitable for: IHC-FoFr, IHC-Fr, RIAmore details
  • Species reactivity

    Reacts with: Rat, Guinea pig, Hamster, Pig, Rhesus monkey
    Predicted to work with: Mouse, Cow, Human, Xenopus laevis
  • Immunogen

    Synthetic peptide:


    , corresponding to amino acids 1-13 of Pig Dynorphin B. (Prodynorphin 228-240).

  • General notes

    This product should be stored undiluted. Storage in frost free freezers is not recommended. Should this product contain a precipitate we recommend microcentrifugation before use.


  • Form

  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • Storage buffer

    Preservative: 0.09% Sodium azide
    Constituents: PBS, Whole serum, 1% BSA
  • Purity

    Whole antiserum
  • Clonality

  • Isotype

  • Research areas


Our Abpromise guarantee covers the use of ab11135 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-FoFr Use at an assay dependent concentration. PubMed: 20206610
IHC-Fr 1/250 - 1/2500.
RIA 1/5000.


  • Function

    Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress.
    Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opiod activity, it is 700 times more potent than Leu-enkephalin.
    Leumorphin has a typical opiod activity and may have anti-apoptotic effect.
  • Involvement in disease

    Defects in PDYN are the cause of spinocerebellar ataxia type 23 (SCA23) [MIM:610245]. Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA23 is an adult-onset autosomal dominant form characterized by slowly progressive gait and limb ataxia, with variable additional features, including peripheral neuropathy and dysarthria.
  • Sequence similarities

    Belongs to the opioid neuropeptide precursor family.
  • Post-translational

    The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing.
  • Cellular localization

  • Information by UniProt
  • Database links

  • Alternative names

    • Beta-neoendorphin-dynorphin antibody
    • Big Dyn antibody
    • Dyn B antibody
    • Dyn-A17 antibody
    • Dyn-B antibody
    • Dynorphin A antibody
    • Dynorphin B antibody
    • Dynorphin B(1-13) antibody
    • Dynorphin B-29 antibody
    • Leumorphin antibody
    • PDYN antibody
    • PDYN_HUMAN antibody
    • Preprodynorphin antibody
    see all


This product has been referenced in:

  • Amrein I & Slomianka L A morphologically distinct granule cell type in the dentate gyrus of the red fox correlates with adult hippocampal neurogenesis. Brain Res 1328:12-24 (2010). IHC-FoFr . Read more (PubMed: 20206610) »
See 1 Publication for this product

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab11135.
Please use the links above to contact us or submit feedback about this product.

For licensing inquiries, please contact partnerships@abcam.com

Sign up