Overview

  • Product name

  • Description

    Rabbit polyclonal to Dyrk1B/MIRK
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Mouse, Rat
    Predicted to work with: Cow, Human, Zebrafish, Rhesus monkey
  • Immunogen

    Recombinant fragment within Human Dyrk1B/MIRK (internal sequence). The exact sequence is proprietary.
    Database link: Q9Y463

  • Positive control

    • WB: Mouse and rat testis extracts.
  • General notes

     This product was previously labelled as Dyrk1B

     

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer

    pH: 7.00
    Preservative: 0.01% Thimerosal (merthiolate)
    Constituents: PBS, 20% Glycerol
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab227135 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 69 kDa.

Target

  • Function

    Dual-specificity kinase which possesses both serine/ threonine and tyrosine kinase activities. Enhances the transcriptional activity of TCF1/HNF1A and FOXO1. Inhibits epithelial cell migration. Mediates colon carcinoma cell survival in mitogen-poor environments.
  • Tissue specificity

    Highest expression in skeletal muscle, testis, heart and brain with little expression in colon or lung. Expressed in a variety of tumor cell lines.
  • Sequence similarities

    Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.
    Contains 1 protein kinase domain.
  • Post-translational
    modifications

    Autophosphorylated on tyrosine residues. Phosphorylated by MAP kinase. Tyrosine phosphorylation may be required for dimerization.
  • Cellular localization

    Nucleus.
  • Information by UniProt
  • Database links

  • Alternative names

    • AOMS3 antibody
    • Dual specificity tyrosine (Y) phosphorylation regulated kinase 1B antibody
    • Dual specificity tyrosine phosphorylation regulated kinase 1B antibody
    • Dual specificity tyrosine-phosphorylation-regulated kinase 1B antibody
    • DYR 1B antibody
    • DYR1A antibody
    • DYR1B antibody
    • DYR1B_HUMAN antibody
    • DYRK 1B antibody
    • Dyrk1b antibody
    • Minibrain related kinase antibody
    • Minibrain-related kinase antibody
    • MIRK antibody
    • Mirk protein kinase antibody
    see all

Images

  • Anti-Dyrk1B/MIRK antibody (ab227135) at 1/500 dilution + Mouse testis extract at 50 µg

    Predicted band size: 69 kDa



    7.5% SDS-PAGE gel.

  • Anti-Dyrk1B/MIRK antibody (ab227135) at 1/500 dilution + Rat testis extract at 50 µg

    Predicted band size: 69 kDa



    7.5% SDS-PAGE gel.

References

ab227135 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab227135.
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